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Table 2 Results from applying a flexible parametric proportional hazards model adjusting for observed baseline systolic blood pressure, and a full joint model using the intercept association structure

From: Adjusting for measurement error in baseline prognostic biomarkers included in a time-to-event analysis: a joint modelling approach

  

Standard FPSM

Joint model

  

Coefficient

95% CI

Coefficient

95% CI

 Survival model:

      
 

Baseline SBP/10 (α 2)

0.105

0.050

0.159

0.181

0.102

0.261

 

Age (years)

0.048

0.036

0.060

0.050

0.038

0.062

 

Sex (male)

0.011

-0.233

0.254

-0.010

-0.253

0.234

 

BMI (kg/m2)

0.011

-0.015

0.037

0.013

-0.012

0.039

 Longitudinal model:

      
 

Intercept

-

-

-

13.006

12.629

13.382

 

Age (years)

-

-

-

0.025

0.022

0.029

 

Sex (male)

-

-

-

-0.252

-0.332

-0.171

 

BMI (kg/m2)

-

-

-

0.003

-0.005

0.011

 

RCS1

-

-

-

-0.080

-0.121

-0.039

 

RCS2

-

-

-

-0.006

-0.019

0.006

 

RCS3

-

-

-

-0.001

-0.010

0.007

 

RCS4

-

-

-

0.003

0.000

0.006

 

RCS5

-

-

-

0.000

-0.001

0.001

 

σ e

-

-

-

1.522

1.515

1.528

  1. FPSM - Flexible Parametric Survival Model.
  2. RCS - Restricted Cubic Spline.