Skip to main content

Table 2 Results from applying a flexible parametric proportional hazards model adjusting for observed baseline systolic blood pressure, and a full joint model using the intercept association structure

From: Adjusting for measurement error in baseline prognostic biomarkers included in a time-to-event analysis: a joint modelling approach

   Standard FPSM Joint model
   Coefficient 95% CI Coefficient 95% CI
 Survival model:       
  Baseline SBP/10 (α 2) 0.105 0.050 0.159 0.181 0.102 0.261
  Age (years) 0.048 0.036 0.060 0.050 0.038 0.062
  Sex (male) 0.011 -0.233 0.254 -0.010 -0.253 0.234
  BMI (kg/m2) 0.011 -0.015 0.037 0.013 -0.012 0.039
 Longitudinal model:       
  Intercept - - - 13.006 12.629 13.382
  Age (years) - - - 0.025 0.022 0.029
  Sex (male) - - - -0.252 -0.332 -0.171
  BMI (kg/m2) - - - 0.003 -0.005 0.011
  RCS1 - - - -0.080 -0.121 -0.039
  RCS2 - - - -0.006 -0.019 0.006
  RCS3 - - - -0.001 -0.010 0.007
  RCS4 - - - 0.003 0.000 0.006
  RCS5 - - - 0.000 -0.001 0.001
  σ e - - - 1.522 1.515 1.528
  1. FPSM - Flexible Parametric Survival Model.
  2. RCS - Restricted Cubic Spline.