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Table 2 Operating characteristics of the test of RMST difference

From: Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

Model Recruit Follow-up t des Sample RMST test Logrank test
  (K 1, yr) (K 2, yr)   size Power Sig. level Power Sig. level
PH 1 7 8 424 89.6 4.6 90.7 4.6
  3 5 8 432 90.1 4.6 90.3 4.7
  5 3 7.5 463 90.9 5.1 90.7 4.9
  7 1 6.7 532 90.5 5.4 90.3 5.1
Non-PH 1 7 4.4 324 89.4 4.5 81.2 4.8
  3 5 4.4 325 90.0 5.0 83.2 5.2
  5 3 4.3 328 89.5 4.3 84.4 4.5
  7 1 3.8 351 91.6 4.8 83.5 5.5
  1. Significance level and power are presented as percentages. Sample size calculations are for hypothetical trials with proportional hazards (PH) or non-proportional hazards (non-PH) of the treatment effect. Results are given for the RMST test and for the logrank test using the RMST designed sample sizes. Details are as given in Table 1.