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Table 3 Design parameters for the SORCE trial

From: Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

Year

Trial plan

Hypothetical

 

DFS prob.

HR (PH)

HR (non-PH)

1

0.779

0.75

0.65

3

0.635

0.75

0.75

5

0.576

0.75

0.85

7

0.532

0.75

0.9

10

0.488

0.75

1.0

13

0.454

0.75

1.0

  1. “DFS prob.” denotes survival probabilities for the disease-free survival outcome. PH and non-PH refer respectively to designs with (as per protocol) and without (hypothetical) proportional hazards of the treatment effect.
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BMC Medical Research Methodology

ISSN: 1471-2288

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