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Table 4 Total sample size ( N ) and t des for hypothetical trials based on the design of SORCE

From: Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

Design K 1 K 2 t des Logrank RMST
  (yr) (yr) (yr) n Events n Events
PH 5 3 8 1656 608 1790 658
  5 5 10 1509 610 1627 658
  5 8 13 1378 612 1488 662
non-PH 5 3 5.4 1621 602 1280 476
  5 5 6.0 1803 751 1266 528
  5 8 8.0 2008 934 1488 692
  1. Recruitment (K 1) is assumed to be for 5 years in all the designs, whereas follow-up (K 2) is varied over 3, 5 and 8 years.