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Table 4 Total sample size ( N ) and t des ∗ for hypothetical trials based on the design of SORCE

From: Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

Design

K 1

K 2

t des ∗

Logrank

RMST

 

(yr)

(yr)

(yr)

n

Events

n

Events

PH

5

3

8

1656

608

1790

658

 

5

5

10

1509

610

1627

658

 

5

8

13

1378

612

1488

662

non-PH

5

3

5.4

1621

602

1280

476

 

5

5

6.0

1803

751

1266

528

 

5

8

8.0

2008

934

1488

692

  1. Recruitment (K 1) is assumed to be for 5 years in all the designs, whereas follow-up (K 2) is varied over 3, 5 and 8 years.