Table 4 Odds ratios and 95% confidence/credible intervals for the four placebo comparisons and two select active intervention comparisons in the second illustrative example
Model | Trt1 vs Placebo | Trt2 vs Placebo | Trt3 vs Placebo | Trt4 vs Placebo | Trt2 vs Trt1 | Trt4 vs Trt2 |
|---|---|---|---|---|---|---|
Random-effects pair wise meta-analysis | ||||||
DerSimonian-Laird | 1.94(1.67-2.24) | 2.11(1.42-3.13) | 1.78(1.60-1.97) | 2.86(2.21-3.71) | 1.90 (1.17-3.09) | -- |
Hartung-Makimbi | 1.94(1.68-2.23) | 2.09(1.42-3.09) | 1.77(1.57-2.00) | 2.86(2.21-3.70) | 1.91 (1.16-3.13) | -- |
Bayesian (non-informative) | 1.98(1.70-2.31) | 2.38(1.30-5.82) | 1.80(1.61-2.02) | 2.89(2.08-4.06) | 1.97 (0.66-8.88) | -- |
Bayesian (frequentist informed) | 1.97(1.71-2.28) | 2.16(1.48-3.68) | 1.80(1.60-2.02) | 2.89(2.23-3.77) | 1.79 (1.17-3.55) | -- |
Bayesian (empirically informed) | 1.97(1.71-2.28) | 2.13(1.47-3.98) | 1.80(1.61-2.03) | 2.89(2.20-3.80) | 1.84 (1.17-3.53) | -- |
Random-effects MTC models | ||||||
Weakly informed variance models | ||||||
Homogeneous variance model | 1.91(1.67-2.19) | 2.59(1.97-3.50) | 1.80(1.57-2.08) | 2.90(2.23-3.79) | 1.36 (1.02-1.84) | 1.11(0.74-1.63) |
Unrestricted variances | 1.95(1.69-2.28) | 3.05(1.84-5.50) | 1.81(1.62-2.01) | 2.90(2.07-4.07) | 1.56 (0.94-2.75) | 0.94(0.49-1.74) |
Exchangeable variances* | 1.93(1.67-2.26) | 2.89(1.98-4.43) | 1.78(1.56-1.99) | 2.89(2.17-3.86) | 1.50 (1.03-2.26) | 1.01(0.59-1.58) |
Consistency variances structure | 1.93(1.66-2.23) | 2.80(1.92-4.69) | 1.80(1.60-2.02) | 2.90(2.18-3.86) | 1.45 (0.99-2.40) | 1.03(0.58-1.66) |
Moderately informed variance models | ||||||
Frequentist informed priors | 1.93(1.68-2.22) | 2.80(1.98-4.10) | 1.80(1.60-2.03) | 2.90(2.22-3.78) | 1.46 (1.02-2.11) | 1.05(0.66-1.61) |
Empirically informed priors | 1.93(1.67-2.23) | 2.84(2.00-4.26) | 1.80(1.61-2.02) | 2.91(2.22-3.81) | 1.48 (1.00-2.20) | 1.02(0.63-1.59) |