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Table 1 Empirical power for all three methods when there was no misspecification of the distribution of the prognostic factor

From: Impact of misspecifying the distribution of a prognostic factor on power and sample size for testing treatment interactions in clinical trials

θ

Planned distribution of the prognostic factor

Planned n t

Quota sampling

Modified quota sampling

Sample size re-estimation using conditional power

5

10%

1,418

0.8088

0.8054

0.8836

20%

798

0.8152

0.8082

0.8916

30%

608

0.8178

0.8014

0.8870

40%

532

0.8116

0.8036

0.8866

50%

512

0.8156

0.8098

0.8974

15

10%

178

0.8556

0.8204

0.8890

20%

100

0.8490

0.8128

0.8930

30%

78

0.8442

0.8316

0.9012

40%

68

0.8556

0.8322

0.9038

50%

64

0.8412

0.8256

0.9082

  1. The margin of error based on the 99% confidence interval is 0.015.