θ | Planned distribution of the prognostic factor | Planned n t | Empirical type I error | Percent stopping for futility | Percent stopping for efficacy |
---|---|---|---|---|---|
Misspecification of the prognostic factor: -5% | |||||
0 | 10% | 1,418 | 0.0278 | 43.48% | 0.24% |
20% | 798 | 0.0264 | 44.54% | 0.26% | |
30% | 608 | 0.0262 | 42.66% | 0.20% | |
40% | 532 | 0.0280 | 44.16% | 0.24% | |
50% | 512 | 0.0246 | 42.88% | 0.30% | |
0 | 10% | 178 | 0.0304 | 42.94% | 0.40% |
20% | 100 | 0.0276 | 42.44% | 0.28% | |
30% | 78 | 0.0252 | 43.16% | 0.54% | |
40% | 68 | 0.0230 | 43.08% | 0.44% | |
50% | 64 | 0.0298 | 42.00% | 0.56% | |
Misspecification of the prognostic factor: -15% | |||||
0 | 10% | 1,418 | -- | -- | -- |
20% | 798 | 0.0254 | 43.62% | 0.24% | |
30% | 608 | 0.0278 | 42.94% | 0.30% | |
40% | 532 | 0.0282 | 44.00% | 0.36% | |
50% | 512 | 0.0248 | 42.62% | 0.32% | |
0 | 10% | 178 | -- | -- | -- |
20% | 100 | 0.0326 | 44.24% | 0.50% | |
30% | 78 | 0.0282 | 42.52% | 0.44% | |
40% | 68 | 0.0286 | 42.62% | 0.42% | |
50% | 64 | 0.0296 | 43.26% | 0.50% | |
Misspecification of the prognostic factor: +5% | |||||
0 | 10% | 1,418 | 0.0314 | 41.46% | 0.36% |
20% | 798 | 0.0284 | 42.94% | 0.22% | |
30% | 608 | 0.0296 | 44.76% | 0.44% | |
40% | 532 | 0.0312 | 43.82% | 0.32% | |
50% | 512 | 0.0290 | 44.16% | 0.36% | |
0 | 10% | 178 | 0.0284 | 43.64% | 0.30% |
20% | 100 | 0.0274 | 43.30% | 0.38% | |
30% | 78 | 0.0296 | 43.66% | 0.44% | |
40% | 68 | 0.0280 | 44.24% | 0.48% | |
50% | 64 | 0.0290 | 43.82% | 0.46% | |
Misspecification of the prognostic factor: +15% | |||||
0 | 10% | 1,418 | 0.0244 | 43.32% | 0.28% |
20% | 798 | 0.0274 | 44.44% | 0.34% | |
30% | 608 | 0.0232 | 43.98% | 0.20% | |
40% | 532 | 0.0290 | 43.18% | 0.32% | |
50% | 512 | 0.0284 | 44.22% | 0.32% | |
0 | 10% | 178 | 0.0282 | 43.36% | 0.38% |
20% | 100 | 0.0282 | 42.50% | 0.36% | |
30% | 78 | 0.0266 | 43.92% | 0.34% | |
40% | 68 | 0.0266 | 44.30% | 0.46% | |
50% | 64 | 0.0248 | 42.48% | 0.34% |