Skip to main content

Table 1 Correlate of protection threshold values τ ^ estimated by a:b model and evaluation criteria for 15 immunological datasets on pertussis, RSV and varicella

From: A threshold method for immunological correlates of protection

Dataset (cases of disease: subjects) τ ^ by profile likelihood (95% CI) τ ^ by least-squares (95% CI) p-value, test for threshold p-value, goodness-of-fit Relative risk(95% CI)
German pertussis FHA IgG (44:1988) 1.995 (1.185;18.13) 1.995 (0.990;2.025) 6.0×10–11 0.114 0.093 (0.030;0.183)
German pertussis PT IgG (44:1987) 1.385 (0.965;1.390) 1.385 (0.755;1.390) 3.2×10–11 0.798 0.055 (0.000;0.133)
German pertussis PRN IgG (44:1992) 13.165 (1.375;29.31) 7.665 (0.855;13.17) 4.1×10–9 0.615 0.052 (0.000;0.141)
German pertussis FIM IgG (44:1986) 0.315 (0.305;4.500) 0.315 (0.215;0.540) 9.1×10–10 0.284 0.111 (0.040;0.216)
German pertussis FHA IgA (44:1932) 0.385 (0.305;1.960) 0.385 (0.315;1.960) 0.344 0.742 0.501 (0.267;1.237)
German pertussis PT IgA (44:1933) 1.785 (0.475;3.179) 1.785 (0.415;4.064) 0.497 0.502 0.554 (0.181;1.120)
German pertussis PRN IgA (44:1968) 2.505 (0.760;2.510) 2.505 (0.485;2.510) 1.4×10–3 0.346 0.000 ( - ; - )
German pertussis FIM IgA (44:1994) 3.385 (1.565;3.830) 1.575 (1.030;3.825) 1.3×10–4 0.159 0.176 (0.037;0.375)
Piedra RSV/A (34:175) 76.109 (5.657;608.9) 76.109 (4.757;215.3) 2.0×10–3 0.918 0.308 (0.163;0.544)
Piedra RSV/B (34:175) 107.635 (8.000;1722) 107.635 (5.657;861.1) 2.7×10–3 0.546 0.305 (0.169;0.548)
White/Varicella (79:3459) 5.011 (2.584;5.011) 2.584 (1.311;5.011) <1.0×10–12 0.085 0.098 (0.053;0.163)
Swedish pertussis FHA IgG (92:209) 1.414 (0.707;6.481) 1.414 (0.707;6.481) 3.5×10–4 0.966 0.508 (0.358;0.687)
Swedish pertussis PT IgG (92:209) 5.477 (1.414;15.49) 5.477 (1.414;10.49) 3.0×10–4 0.999 0.391 (0.199;0.614)
Swedish pertussis PRN IgG (92:209) 5.950 (2.298;15.92) 5.950 (1.497;6.380) 5.1×10–10 0.921 0.130 (0.030;0.270)
Swedish pertussis FIM IgG (92:209) 7.650 (1.249;7.846) 4.225 (1.249;7.846) 2.2×10–09 0.781 0.177 (0.056;0.325)
  1. for τ ^ found by profile likelihood.