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Table 1 Correlate of protection threshold values τ ^ estimated by a:b model and evaluation criteria for 15 immunological datasets on pertussis, RSV and varicella

From: A threshold method for immunological correlates of protection

Dataset (cases of disease: subjects)

τ ^ by profile likelihood (95% CI)

τ ^ by least-squares (95% CI)

p-value, test for threshold

p-value, goodness-of-fit

Relative risk(95% CI)

German pertussis FHA IgG (44:1988)

1.995 (1.185;18.13)

1.995 (0.990;2.025)

6.0×10–11

0.114

0.093 (0.030;0.183)

German pertussis PT IgG (44:1987)

1.385 (0.965;1.390)

1.385 (0.755;1.390)

3.2×10–11

0.798

0.055 (0.000;0.133)

German pertussis PRN IgG (44:1992)

13.165 (1.375;29.31)

7.665 (0.855;13.17)

4.1×10–9

0.615

0.052 (0.000;0.141)

German pertussis FIM IgG (44:1986)

0.315 (0.305;4.500)

0.315 (0.215;0.540)

9.1×10–10

0.284

0.111 (0.040;0.216)

German pertussis FHA IgA (44:1932)

0.385 (0.305;1.960)

0.385 (0.315;1.960)

0.344

0.742

0.501 (0.267;1.237)

German pertussis PT IgA (44:1933)

1.785 (0.475;3.179)

1.785 (0.415;4.064)

0.497

0.502

0.554 (0.181;1.120)

German pertussis PRN IgA (44:1968)

2.505 (0.760;2.510)

2.505 (0.485;2.510)

1.4×10–3

0.346

0.000 ( - ; - )

German pertussis FIM IgA (44:1994)

3.385 (1.565;3.830)

1.575 (1.030;3.825)

1.3×10–4

0.159

0.176 (0.037;0.375)

Piedra RSV/A (34:175)

76.109 (5.657;608.9)

76.109 (4.757;215.3)

2.0×10–3

0.918

0.308 (0.163;0.544)

Piedra RSV/B (34:175)

107.635 (8.000;1722)

107.635 (5.657;861.1)

2.7×10–3

0.546

0.305 (0.169;0.548)

White/Varicella (79:3459)

5.011 (2.584;5.011)

2.584 (1.311;5.011)

<1.0×10–12

0.085

0.098 (0.053;0.163)

Swedish pertussis FHA IgG (92:209)

1.414 (0.707;6.481)

1.414 (0.707;6.481)

3.5×10–4

0.966

0.508 (0.358;0.687)

Swedish pertussis PT IgG (92:209)

5.477 (1.414;15.49)

5.477 (1.414;10.49)

3.0×10–4

0.999

0.391 (0.199;0.614)

Swedish pertussis PRN IgG (92:209)

5.950 (2.298;15.92)

5.950 (1.497;6.380)

5.1×10–10

0.921

0.130 (0.030;0.270)

Swedish pertussis FIM IgG (92:209)

7.650 (1.249;7.846)

4.225 (1.249;7.846)

2.2×10–09

0.781

0.177 (0.056;0.325)

  1. for τ ^ found by profile likelihood.