Skip to main content

Table 3 The use of systematic reviews in trial design

From: The use of systematic reviews in the planning, design and conduct of randomised trials: a retrospective cohort of NIHR HTA funded trials

Area of use Number of applications (%)
  (n=37)
Justification of treatment comparisons 6 (16.2)
Choice of frequency/dose 2 (5.4)
Selection or definition of outcome 7 (18.9)
Recruitment and consent 2 (5.4)
Estimating the difference to detect or margin of equivalence 6 (16.2)
Estimating the control group event rate 3 (8.1)
Inform standard deviation 1 (2.7)
Duration of follow up 8 (21.6)
Withdrawal rate 1 (2.7)
Adverse events 9 (24.3)