Table 2 Registry-based algorithm based on treatment protocol name and details of each treatment protocol

AALL02P2

T

≥10 (or)*

≥50 (or)

HR

AALL0031

t(9;22) or hypodiploidy or MLL with slow response (or)

Induction failure (or)

HR

AALL0232

B

≥10 (or)

≥50 (or)

Steroid pre treatment (or)

HR

AALL0331

B

1-9

<50

SR

AALL0434

T

>1

HR

AALL0622

>1

t(9;22)

HR

AALL0631

<1

HR

AALL0932

B

1-9

<50

No t(9;22), MLL, iAMP21, hypodiploidy

SR

CCG1991

B

1-9

<50

SR

POG9201

B

1-9

<50

Trisomy 4,10, DI>1.16 or t(12;21); No t(9;22), 1;19, MLL

SR

POG9407

<1

HR

POG9605

B

1-9

<50

No trisomy 4,10, DI>1.16, MLL, t(1;19), t(9;22)

SR

B

≥10

<50

Trisomy 4,10 or DI>1.16; No MLL, t(1;19), t(9;22)

SR

B

>1

≥50

Trisomy 4,10 or DI>1.16; No MLL, t(1;19), t(9;22)

SR

POG9904

B

1-9

<50

Trisomy 4,10, DI>1.16 or t(12;21); No MLL, t(1;19), t(9;22)

SR

POG9905

Neither 9904, 9906 nor AALL0031

SR

POG9906

B

M>12; F>16 (or)

>100 (or)

MLL (or)

HR

B

Sliding scale of WBC criteria for M age 8–11 and F age 12-15

HR

Protocol C

<1 or >10 (or)

>20 (or)

t(9;22) or MLL (or)

L2 morphology, mediastinal mass, or massive LN/HSM

HR