Table 3 Disease-related characteristics of overall study cohort and distribution of each characteristic by biology-based algorithms (N=579)
Algorithm 1* | Algorithm 2* | Algorithm 3* | Algorithm 4* | ||||||
|---|---|---|---|---|---|---|---|---|---|
Age, WBC | Algorithm 1+ immunophenotype | Algorithm 2+cytogenetics | Algorithm 3+MRD | ||||||
Overall | SR | HR | SR | HR | SR | HR | SR | HR | |
Overall | 579 (100) | 359 (62) | 220 (38) | 347 (60) | 232 (40) | 340 (59) | 239 (41) | 324 (56) | 255 (44) |
Immunophenotype | |||||||||
B | 522 (90) | 347 (66) | 175 (34) | 347 (66) | 175 (34) | 340 (65) | 182 (35) | 324 (62) | 198 (10) |
T | 57 (10) | 12 (21) | 45 (79) | 0 (0) | 57 (100) | 0 (0) | 57 (100) | 0 (0) | 57 (100) |
Cytogenetics | |||||||||
High risk | 36 (6) | 7 (19) | 29 (81) | 7 (19) | 29 (81) | 0 (0) | 36 (100) | 0 (0) | 36 (100) |
MLL rearrangement | 19 (3) | 3 (16) | 16 (84) | 3 (16) | 16 (84) | 0 (0) | 19 (100) | 0 (0) | 19 (100) |
t(9;22) (BCR-ABL) | 10 (2) | 2 (20) | 8 (80) | 2 (20) | 8 (80) | 0 (0) | 10 (100) | 0 (0) | 10 (100) |
Hypodiploidy | 7 (1) | 2 (29) | 5 (71) | 2 (29) | 5 (71) | 0 (0) | 7 (100) | 0 (0) | 7 (100) |
Standard risk | 542 (94) | 352 (65) | 190 (35) | 340 (63) | 202 (37) | 340 (63) | 202 (37) | 324 (60) | 218 (40) |
Hyperdiploidy | 183 (32) | 147 (80) | 36 (20) | 147 (80) | 36 (20) | 147 (80) | 36 (20) | 143 (78) | 40 (22) |
t(12;21) (TEL-AML) | 144 (25) | 116 (81) | 28 (19) | 116 (81) | 28 (19) | 116 (81) | 28 (19) | 115 (80) | 29 (20) |
t(1;19) (E2A-PBX) | 22 (4) | 12 (55) | 10 (45) | 12 (55) | 10 (45) | 12 (55) | 10 (45) | 10 (45) | 12 (55) |
No specific lesion | 193 (33) | 77 (40) | 116 (60) | 65 (34) | 128 (66) | 65 (34) | 128 (66) | 56 (29) | 137 (71) |
Missing | 1 (0) | 0 (0) | 1 (100) | 0 (0) | 1 (100) | 0 (0) | 1 (100) | 0 (0) | 1 (100) |
MRD | |||||||||
Negative | 258 (45) | 189 (73) | 69 (27) | 189 (73) | 69 (27) | 185 (72) | 73 (28) | 185 (72) | 73 (28) |
Positive | 38 (5) | 18 (47) | 20 (53) | 18 (47) | 20 (53) | 16 (42) | 22 (58) | 0 (0) | 38 (100) |
Died prior to test | 6 (1) | 1 (17) | 5 (83) | 1 (17) | 5 (83) | 1 (17) | 5 (83) | 1 (17) | 5 (83) |
Not performed | 277 (48) | 151 (55) | 126 (45) | 139 (50) | 138 (50) | 139 (50) | 138 (50) | 139 (50) | 138 (50) |