| |
Algorithm 1*
|
Algorithm 2*
|
Algorithm 3*
|
Algorithm 4*
|
|---|
| |
Age, WBC
|
Algorithm 1+ immunophenotype
|
Algorithm 2+cytogenetics
|
Algorithm 3+MRD
|
|---|
| |
Overall
|
SR
|
HR
|
SR
|
HR
|
SR
|
HR
|
SR
|
HR
|
|---|
|
Overall
|
579 (100)
|
359 (62)
|
220 (38)
|
347 (60)
|
232 (40)
|
340 (59)
|
239 (41)
|
324 (56)
|
255 (44)
|
|
Immunophenotype
| | | | | | | | | |
|
B
|
522 (90)
|
347 (66)
|
175 (34)
|
347 (66)
|
175 (34)
|
340 (65)
|
182 (35)
|
324 (62)
|
198 (10)
|
|
T
|
57 (10)
|
12 (21)
|
45 (79)
|
0 (0)
|
57 (100)
|
0 (0)
|
57 (100)
|
0 (0)
|
57 (100)
|
|
Cytogenetics
| | | | | | | | | |
|
High risk
|
36 (6)
|
7 (19)
|
29 (81)
|
7 (19)
|
29 (81)
|
0 (0)
|
36 (100)
|
0 (0)
|
36 (100)
|
|
MLL rearrangement
|
19 (3)
|
3 (16)
|
16 (84)
|
3 (16)
|
16 (84)
|
0 (0)
|
19 (100)
|
0 (0)
|
19 (100)
|
|
t(9;22) (BCR-ABL)
|
10 (2)
|
2 (20)
|
8 (80)
|
2 (20)
|
8 (80)
|
0 (0)
|
10 (100)
|
0 (0)
|
10 (100)
|
|
Hypodiploidy
|
7 (1)
|
2 (29)
|
5 (71)
|
2 (29)
|
5 (71)
|
0 (0)
|
7 (100)
|
0 (0)
|
7 (100)
|
|
Standard risk
|
542 (94)
|
352 (65)
|
190 (35)
|
340 (63)
|
202 (37)
|
340 (63)
|
202 (37)
|
324 (60)
|
218 (40)
|
|
Hyperdiploidy
|
183 (32)
|
147 (80)
|
36 (20)
|
147 (80)
|
36 (20)
|
147 (80)
|
36 (20)
|
143 (78)
|
40 (22)
|
|
t(12;21) (TEL-AML)
|
144 (25)
|
116 (81)
|
28 (19)
|
116 (81)
|
28 (19)
|
116 (81)
|
28 (19)
|
115 (80)
|
29 (20)
|
|
t(1;19) (E2A-PBX)
|
22 (4)
|
12 (55)
|
10 (45)
|
12 (55)
|
10 (45)
|
12 (55)
|
10 (45)
|
10 (45)
|
12 (55)
|
|
No specific lesion
|
193 (33)
|
77 (40)
|
116 (60)
|
65 (34)
|
128 (66)
|
65 (34)
|
128 (66)
|
56 (29)
|
137 (71)
|
|
Missing
|
1 (0)
|
0 (0)
|
1 (100)
|
0 (0)
|
1 (100)
|
0 (0)
|
1 (100)
|
0 (0)
|
1 (100)
|
|
MRD
| | | | | | | | | |
|
Negative
|
258 (45)
|
189 (73)
|
69 (27)
|
189 (73)
|
69 (27)
|
185 (72)
|
73 (28)
|
185 (72)
|
73 (28)
|
|
Positive
|
38 (5)
|
18 (47)
|
20 (53)
|
18 (47)
|
20 (53)
|
16 (42)
|
22 (58)
|
0 (0)
|
38 (100)
|
|
Died prior to test
|
6 (1)
|
1 (17)
|
5 (83)
|
1 (17)
|
5 (83)
|
1 (17)
|
5 (83)
|
1 (17)
|
5 (83)
|
|
Not performed
|
277 (48)
|
151 (55)
|
126 (45)
|
139 (50)
|
138 (50)
|
139 (50)
|
138 (50)
|
139 (50)
|
138 (50)
|
- All values represent N (%).
-
IQ , Interquartile range; HR, High risk; MRD, Minimally residual disease; N, Number; SR, Standard risk; WBC, White blood cell.
