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Table 3 Disease-related characteristics of overall study cohort and distribution of each characteristic by biology-based algorithms (N=579)

From: Validation of a registry-derived risk algorithm based on treatment protocol as a proxy for disease risk in childhood acute lymphoblastic leukemia

  Algorithm 1* Algorithm 2* Algorithm 3* Algorithm 4*
  Age, WBC Algorithm 1+ immunophenotype Algorithm 2+cytogenetics Algorithm 3+MRD
  Overall SR HR SR HR SR HR SR HR
Overall 579 (100) 359 (62) 220 (38) 347 (60) 232 (40) 340 (59) 239 (41) 324 (56) 255 (44)
Immunophenotype          
  B 522 (90) 347 (66) 175 (34) 347 (66) 175 (34) 340 (65) 182 (35) 324 (62) 198 (10)
  T 57 (10) 12 (21) 45 (79) 0 (0) 57 (100) 0 (0) 57 (100) 0 (0) 57 (100)
Cytogenetics          
  High risk 36 (6) 7 (19) 29 (81) 7 (19) 29 (81) 0 (0) 36 (100) 0 (0) 36 (100)
   MLL rearrangement 19 (3) 3 (16) 16 (84) 3 (16) 16 (84) 0 (0) 19 (100) 0 (0) 19 (100)
   t(9;22) (BCR-ABL) 10 (2) 2 (20) 8 (80) 2 (20) 8 (80) 0 (0) 10 (100) 0 (0) 10 (100)
   Hypodiploidy 7 (1) 2 (29) 5 (71) 2 (29) 5 (71) 0 (0) 7 (100) 0 (0) 7 (100)
  Standard risk 542 (94) 352 (65) 190 (35) 340 (63) 202 (37) 340 (63) 202 (37) 324 (60) 218 (40)
   Hyperdiploidy 183 (32) 147 (80) 36 (20) 147 (80) 36 (20) 147 (80) 36 (20) 143 (78) 40 (22)
   t(12;21) (TEL-AML) 144 (25) 116 (81) 28 (19) 116 (81) 28 (19) 116 (81) 28 (19) 115 (80) 29 (20)
   t(1;19) (E2A-PBX) 22 (4) 12 (55) 10 (45) 12 (55) 10 (45) 12 (55) 10 (45) 10 (45) 12 (55)
   No specific lesion 193 (33) 77 (40) 116 (60) 65 (34) 128 (66) 65 (34) 128 (66) 56 (29) 137 (71)
  Missing 1 (0) 0 (0) 1 (100) 0 (0) 1 (100) 0 (0) 1 (100) 0 (0) 1 (100)
MRD          
  Negative 258 (45) 189 (73) 69 (27) 189 (73) 69 (27) 185 (72) 73 (28) 185 (72) 73 (28)
  Positive 38 (5) 18 (47) 20 (53) 18 (47) 20 (53) 16 (42) 22 (58) 0 (0) 38 (100)
  Died prior to test 6 (1) 1 (17) 5 (83) 1 (17) 5 (83) 1 (17) 5 (83) 1 (17) 5 (83)
  Not performed 277 (48) 151 (55) 126 (45) 139 (50) 138 (50) 139 (50) 138 (50) 139 (50) 138 (50)
  1. All values represent N (%).
  2. IQ , Interquartile range; HR, High risk; MRD, Minimally residual disease; N, Number; SR, Standard risk; WBC, White blood cell.