Validation of a registry-derived risk algorithm based on treatment protocol as a proxy for disease risk in childhood acute lymphoblastic leukemia

Table 4 Measures of agreement between the registry-based algorithm and the biology-based algorithms*

Biology-based algorithms	Sensitivity	Specificity	PPV	NPV	Kappa, 95^thCI
Algorithm 1 (Age, WBC)	0.95	0.88	0.83	0.97	0.80 (0.76-0.86)
Algorithm 2 (Age, WBC, immunophenotype)	0.95	0.91	0.88	0.97	0.85 (0.81-0.89)
Algorithm 3 (Age, WBC, immunophenotype, cytogenetics)	0.94	0.96	0.89	0.96	0.85 (0.81-0.90)
Algorithm 4 (Age, WBC, immunophenotype, cytogenetics, MRD)	0.90	0.93	0.91	0.92	0.83 (0.78-0.87)

*Note that sensitivity, specificity, PPV and NPV were calculated for the ability of the registry-based algorithm to correctly identify high risk patients as defined by the various biology-based algorithms.
CI, Confidence interval; MRD, Minimally residual disease; NPV, Negative predictive value; PPV, Positive predictive value; WBC, White blood cell.

ISSN: 1471-2288