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Table 4 Measures of agreement between the registry-based algorithm and the biology-based algorithms*

From: Validation of a registry-derived risk algorithm based on treatment protocol as a proxy for disease risk in childhood acute lymphoblastic leukemia

Biology-based algorithms Sensitivity Specificity PPV NPV Kappa, 95thCI
Algorithm 1 (Age, WBC) 0.95 0.88 0.83 0.97 0.80 (0.76-0.86)
Algorithm 2 (Age, WBC, immunophenotype) 0.95 0.91 0.88 0.97 0.85 (0.81-0.89)
Algorithm 3 (Age, WBC, immunophenotype, cytogenetics) 0.94 0.96 0.89 0.96 0.85 (0.81-0.90)
Algorithm 4 (Age, WBC, immunophenotype, cytogenetics, MRD) 0.90 0.93 0.91 0.92 0.83 (0.78-0.87)
  1. *Note that sensitivity, specificity, PPV and NPV were calculated for the ability of the registry-based algorithm to correctly identify high risk patients as defined by the various biology-based algorithms.
  2. CI, Confidence interval; MRD, Minimally residual disease; NPV, Negative predictive value; PPV, Positive predictive value; WBC, White blood cell.