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Figure 2 | BMC Medical Research Methodology

Figure 2

From: Inference of synergy/antagonism between anticancer drugs from the pooled analysis of clinical trials

Figure 2

Clinical synergy and antagosnism. The observed ORRs (ORR0) as a function of the expected ORR assuming there are no agent-agent interactions (ORR1). Panels a)-c) show results obtained from the simulation of clinical trials with the reported sample sizes (see Methods). The red color intensity is proportional to fraction of times that a two-agent combination with the corresponding observed ORR0 and expected ORR1 is dimmed non-interacting. d) The results obtained for the two-agent combinations in the clinical data. The diagonal line represents the perfect agreement between the two. Circles represent combinations with evidence for synergy (p synergy  < 0.05), squares represent combinations with evidence for antagonism (p antagonism  < 0.05), and the pluses represent combinations without evidence for synergy or antagonism (p synergy ≥0.05 and p antagonism ≥0.05).

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