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Table 2 All interventions reported in ClinicalTrials.gov register and abstract that were classified as disagreements

From: ClinicalTrials.gov registration can supplement information in abstracts for systematic reviews: a comparison study

 

Abstract

ClinicalTrials.gov

1

1. lutein, zeaxanthin and long chain polyunsaturated fatty acids (LCPUFAs)

1. lutein, zeaxanthin, and 3 omega polyunsaturated fatty acid (PUFA)

2. lutein and zeaxanthin

2. placebo for 3 omega (PUFA)

3. LCPUFAs, docosahexanoic acid, and eicosapentanoic acid

3. placebo for lutein, zeaxanthin and 3 omega PUFA

4. 4 mg triamcinolone

5. 1 mg triamcinolone

6. standard of care

2

1. 0.5D lens, head fixed

1. spectacle lenses

2. 0.5D lens, head free

2. different spectacle lenses

3. 1.0D lens, head fixed

4. 1.0D lens, head free

5. plano lens, head fixed

6. plano lens, head free

3

1. folic acid, vitamin B6 and vitamin B12

1. aspirin ± vitamin E

2. placebo

2. vitamin E ± vitamin C

3. vitamin E ± vitamin C ± beta carotene ± folate

4. placebo

4

1. photocoagulation using ETDRS grid

1. 810 nm diode laser photocoagulation

2. photocoagulation with normal micro-pulsed technique

2. argon laser photocoagulation

3. photocoagulation with high density micro-pulsed technique

5

1. 0.3 mg ranibizumab monthly for 6 months

1. treatment with ranibizumab until resolution of macular edema or as macular edema occurs

2. 0.5 mg ranibizumab monthly for 6 months

2. treatment with ranibizumab until resolution of edema and pigment epithelial detachment or as macular edema or pigment epithelial detachment occur

3. 3 doses of ranibizumab, then treatment until macular fluid or pigment epithelial detachment absent

6

1. laser photocoagulation

1. early treatment

2. conventional treatment

2. standard of care

7

1. SofFlex IOL

1. Acrysof Natural lens

2. SofPort IOL

2. AmoSensar Lens

8

1. plano lens plus weekend atropine

1. patching plus near activities at least one hour per day

2. weekend atropine

2. atropine plus near activities at least one hour per day

3. full spectacle correction plus weekend atropine

4. 2 hours daily patching

9

1. contact lens care system with polyquaternium-1 and MAPD

1. silicone hydrogel contact lens

2. contact lens care system with PHMB

2. 1XPMBH preserved MPS

3. 1XPolyguad/Aldox MPS