Table 3 Exposure to proton pump inhibitors and risk of hospitalisation for pneumonia; self- controlled case-series adjusted analysis
Risk periods | Number of hospitalizations for pneumonia | Person-years | Adjusted* rate ratios (95% CI) | Adjusted** rate ratios (95% CI) |
|---|---|---|---|---|
Baseline unexposed to a proton pump inhibitor | ||||
Unexposed | 5544 | 18632 | 1.0 | 1.0 |
Pre-exposure to a proton pump inhibitor | ||||
Pre 1–30 days | 476 | 383 | 5.24 (4.94 – 5.57) | 5.17 (4.86 – 5.49) |
Pre 31–60 days | 166 | 353 | 2.02 (1.85 – 2.20) | 2.00 (1.83 – 2.18) |
Pre 61–120 days | 148 | 589 | 1.09 (0.99 – 1.19) | 1.07 (0.98 – 1.17) |
Post-exposure to proton pump inhibitors | ||||
1–7 days | 69 | 90 | 3.22 (2.83 – 3.66) | 3.07 (2.69 – 3.50) |
8–30 days | 135 | 287 | 2.01 (1.82 – 2.21) | 2.00 (1.82 – 2.20) |
>30 days | 1131 | 2978 | 1.67 (1.58 – 1.77) | 1.66 (1.56 – 1.76) |