Table 4 Sensitivity analysis: exposure to PPIs and risk of hospitalisation for pneumonia; self - controlled case - series adjusted analysis in patients alive at discharge
Risk periods | Number of hospitalizations for pneumonia | Person-years | Adjusted* rate ratios (95% CI) |
|---|---|---|---|
Baseline unexposed to a proton pump inhibitor | |||
Unexposed | 4680 | 16676 | 1.0 |
Pre-exposure to a proton pump inhibitor | |||
Pre 1–30 days | 438 | 347 | 5.71 (5.37 – 6.07) |
Pre 31–60 days | 161 | 319 | 2.30 (2.11 – 2.51) |
Pre 61–120 days | 141 | 530 | 1.21 (1.11 – 1.33) |
Post-exposure to proton pump inhibitors | |||
1–7 days | 52 | 81 | 2.87 (2.49 – 3.32) |
8–30 days | 112 | 262 | 1.95 (1.76 – 2.16) |
>30 days | 944 | 2786 | 1.55 (1.46 – 1.65) |