M1b Sample | Concurrent BM claims algorithm 3 | No concurrent BM claims algorithm 3 | p-value | ||||
---|---|---|---|---|---|---|---|
N = 1,694 | N = 813 | N = 881 | |||||
(48.0%) | (52.0%) | ||||||
N | Col% | N | Col% | N | Col% | ||
Post-diagnosis resource utilization (i.e., till end of follow-up) | |||||||
Bone mineral density (BMD) test | 71 | 4.2 | 28 | 3.5 | 43 | 4.9 | 0.14 |
PSA test | 1,389 | 82.0 | 640 | 78.7 | 749 | 85.0 | <0.01 |
Oncologist visit | 1,041 | 61.5 | 567 | 69.7 | 474 | 53.8 | <0.01 |
Nuclear medicine specialist visit | NR | NR | NR | + | NR | - | 0.10 |
Radiation oncologist visit | 687 | 40.6 | 369 | 45.4 | 318 | 36.1 | <0.01 |
Bone biopsy | 47 | 2.8 | NR | + | NR | - | <0.01 |
Bone or joint imaging | 1,406 | 83.0 | 684 | 84.1 | 722 | 82.0 | 0.23 |
Treatment receipt (Part B) | |||||||
Radiation | 581 | 34.3 | 315 | 38.8 | 266 | 30.2 | <0.01 |
External beam radiation therapy | 553 | 32.6 | 302 | 37.2 | 251 | 28.5 | <0.01 |
Radiopharmaceutical therapy | 72 | 4.3 | 45 | 5.5 | 27 | 3.1 | 0.01 |
Bisphosphonates IV | 593 | 35.0 | 351 | 43.2 | 242 | 27.5 | <0.01 |
Erythropoietin | 352 | 20.8 | 192 | 23.6 | 160 | 18.2 | 0.01 |
Opioids (moderate-severe) | 379 | 22.4 | 167 | 20.5 | 212 | 24.1 | 0.08 |
Resource utilization during the 90-day diagnosis period | |||||||
PSA test | 1,046 | 61.8 | 481 | 59.2 | 565 | 64.1 | 0.04 |
Bone biopsy | 42 | 2.5 | NR | + | NR | - | <0.01 |
Bone or joint imaging | 1317 | 77.7 | 690 | 84.9 | 627 | 71.2 | <0.01 |
Mean | S.D. | Mean | S.D. | Mean | S.D. | p-value | |
Post-diagnosis resource utilization (i.e., till end of follow-up) | |||||||
Number of BMD tests | 0.04 | 0.22 | 0.04 | 0.19 | 0.05 | 0.24 | 0.11 |
Number of PSA tests | 8.81 | 10.41 | 8.80 | 10.90 | 8.83 | 9.95 | 0.95 |
Number of bone biopsies | 0.03 | 0.18 | 0.05 | 0.24 | 0.01 | 0.09 | <0.01 |
Number of bone or joint imaging | 1.73 | 1.61 | 1.70 | 1.56 | 1.75 | 1.66 | 0.51 |
Resource utilization during the 90-day diagnosis period | |||||||
Number of PSA tests | 0.92 | 0.94 | 0.95 | 1.04 | 0.89 | 0.83 | 0.18 |
Number of bone biopsies | 0.03 | 0.17 | 0.05 | 0.24 | 0.003 | 0.06 | <0.01 |
Number of bone or joint imaging | 0.79 | 0.44 | 0.87 | 0.41 | 0.72 | 0.47 | <0.01 |