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Table 2 Parameter estimates from the alternative MTC synthesis models

From: Network meta-analysis of (individual patient) time to event data alongside (aggregate) count data

  Model A Model B Model C1 Model C2 Model D
Hazard ratios HR Median (95% CrI) P HR Median (95% CrI) P HR Median (95% CrI) P HR Median (95% CrI) P HR Median (95% CrI) P
Treatment effects 4LB 5.5 1.4 6.2 5.7 4.3
SSB 0.88 (0.76, 1.03) 0.4 0.96 (0.77, 1.22) 0.6 0.89 (0.77, 1.04) 0.6 0.89 (0.77, 1.04) 0.6 0.84 (0.70, 0.99) 0.2
HH 1.05 (0.85, 1.29) 16.1 1.63 (0.76, 3.53) 59.2 1.03 (0.83, 1.27) 14.9 1.03 (0.84, 1.27) 15.0 1.03 (0.84, 1.28) 11.1
ZINC 0.77 (0.41, 1.42) 6.2 0.78 (0.37, 1.62) 2.8 0.78 (0.41, 1.44) 6.5 0.78 (0.41, 1.43) 6.7 0.75 (0.03, 29.49) 17.5
2LB 1.40 (0.65, 3.05) 71.9 1.39 (0.62, 3.30) 36.0 1.38 (0.66, 3.05) 71.8 1.38 (0.63, 3.04) 72.0 1.59 (0.61, 5.34) 67.0
Baseline characteristics Log area 0.71 (0.66, 0.76) 0.71 (0.66, 0.76) 0.70 (0.65, 0.75) 0.70 (0.65, 0.75) 0.71 (0.65, 0.76)
Log duration 0.92 (0.90, 0.94) 0.92 (0.90, 0.94) 0.92 (0.91, 0.94) 0.93 (0.91, 0.94) 0.92 (0.90, 0.94)
Difficulty in walking 0.71 (0.60, 0.85) 0.73 (0.60, 0.86) 0.72 (0.60, 0.85) 0.72 (0.60, 0.85) 0.71 (0.60, 0.80)
Immobile 0.67 (0.23, 1.52) 0.66 (0.23, 1.51) 0.72 (0.24, 1.65) 0.72 (0.25, 1.67) 0.68 (0.24, 1.59)
Interactions Log area 1.00 (0.97, 1.10)
Log duration 1.00 (0.99, 1.00)
  Btw-centre SD 0.04 (0.01, 0.13) 0.05 (0.01, 0.13) 0.05 (0.01, 0.15) 0.05 (0.01, 0.15)   
  Btw-study SD 0.13 (0.01, 0.51)
  λ 1.07 (1.01, 1.13) 1.07 (1.01, 1.14) λ 1 ** 0.93 (0.86, 1.01) λ 1 0.93 (0.86, 1.01) 1.07 (1.01, 1.14)
        λ 2 1.27 (1.17, 1.38) λ 2 ** 1.27 (1.17, 1.38)     
  DIC 5396.2 5396.2 5371.2 5371.5 5377.4
  1. Model A – Fixed-effects NMA, Weibull model of IPD+AD; model B – Random-effects NMA, Weibull model of IPD+AD; model C1 - Fixed-effects NMA, Weibull model of IPD+AD, shape parameter derived from IPD study 1 only; model C2 - Fixed-effects NMA, Weibull model of IPD+AD, shape parameter derived from IPD study 2 only; model D - Fixed-effects NMA, Weibull model of IPD+AD, considering 2 treatment-effect modifiers.
  2. **Shape parameter used in the synthesis model section for summary data.
  3. 4LB = four layer bandage; SSB = Short stretch bandage; HH = two layer hosiery; 2LB = two layer bandage.
  4. HR = hazard ratios; CrI = credibility interval; SD = standard deviation; P = probability of being the best treatment choice in terms of healing (%); DIC – deviance information criteria.