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Table 2 Application of the test with networks of antidepressant and antipsychotic trials

From: A test for reporting bias in trial networks: simulation and case studies

Antidepressant trials       
  Published data FDA data
  (N =51 trials) (N =74 trials)
Plausible effects O E p O E p
Fixed-effect summary 41 35.3 0.05 38 34.5 0.24
Random-effects summary 41 35.6 0.06 38 34.6 0.25
Largest trial 41 31.3 0.002 38 29.0 0.02
Antipsychotic trials       
  Published data FDA data
  (N =20 trials) (N =24 trials)
Plausible effects O E p O E p
Fixed-effect summary 19 18.1 0.43 20 19.6 0.53
Random-effects summary 19 18.4 0.50 20 34.6 0.56
Largest trial 19 16.1 0.10 20 18.6 0.36
  1. O and E are the observed and expected total numbers of trials with statistically significant results across the network; p is the p-value associated with a one-tail binomial probability test to asssess if O is greater than the E.