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Table 2 Application of the test with networks of antidepressant and antipsychotic trials

From: A test for reporting bias in trial networks: simulation and case studies

Antidepressant trials

      
 

Published data

FDA data

 

(N =51 trials)

(N =74 trials)

Plausible effects

O

E

p

O

E

p

Fixed-effect summary

41

35.3

0.05

38

34.5

0.24

Random-effects summary

41

35.6

0.06

38

34.6

0.25

Largest trial

41

31.3

0.002

38

29.0

0.02

Antipsychotic trials

      
 

Published data

FDA data

 

(N =20 trials)

(N =24 trials)

Plausible effects

O

E

p

O

E

p

Fixed-effect summary

19

18.1

0.43

20

19.6

0.53

Random-effects summary

19

18.4

0.50

20

34.6

0.56

Largest trial

19

16.1

0.10

20

18.6

0.36

  1. O and E are the observed and expected total numbers of trials with statistically significant results across the network; p is the p-value associated with a one-tail binomial probability test to asssess if O is greater than the E.
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BMC Medical Research Methodology

ISSN: 1471-2288

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