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Table 1 3 × 2 table accounting for prevalence and missing index test results

From: A trivariate meta-analysis of diagnostic studies accounting for prevalence and non-evaluable subjects: re-evaluation of the meta-analysis of coronary CT angiography studies

 

Gold standard

Index test

+

−

Total

 

n i11

n i10

n i1+

+

(1−ω i m1)π i S e i

(1−ω i m0)(1−π i )(1−S p i )

(1−ω i m1)π i S e i +(1−ω i m0)(1−π i )(1−S p i )

 

n i01

n i00

n i0+

−

(1−ω i m1)π i (1−S e i )

(1−ω i m0)(1−π i )S p i

(1−ω i m1)π i (1−S e i )+(1−ω i m0)(1−π i )S p i

 

n i m1

n i m0

n i m+

Missing

ω i m1 π i

ω i m0(1−π i )

ω i m1 π i +ω i m0(1−π i )

 

n i+1

n i+0

n i++

Total

Ï€ i

1−π i

1

  1. Each cell reports the cell count and cell probability corresponding to a combination of index test and disease outcomes in study i. n itd denotes the cell counts in study i with index test outcome T =t and reference test outcome D =d, where t = 1,0,m stands for positive, negative and missing, and d = 1,0 denotes positive and negative. Se i , Sp i and π i are sensitivity, specificity and prevalence of study i, respectively. ω imd denotes the missing probability of index test given disease status d in study i.