Table 4 Mutations in mRNA sub-types a
From: Genomic investigation of etiologic heterogeneity: methodologic challenges
Gene | # Cases | Sub-type 1 | Sub-type 2 | Sub-type 3 | Sub-type 4 | p-value |
|---|---|---|---|---|---|---|
n = 74 | n = 83 | n = 71 | n = 85 | |||
VHL | 162 | 58% | 54% | 39% | 69% | .003 |
PBRM1 | 97 | 32% | 39% | 12% | 46% | <.001 |
SETD2 | 36 | 10% | 14% | 12% | 12% | .90 |
BAP1 | 33 | 13% | 6% | 24% | 5% | .001 |
MTOR | 22 | 6% | 9% | 7% | 9% | .90 |
ADAM6 | 22 | 4% | 6% | 4% | 14% | .07 |
MST1P2 | 22 | 6% | 10% | 6% | 8% | .76 |
PDE4DIP | 18 | 7% | 3% | 6% | 9% | .48 |
KDM5C | 17 | 10% | 6% | 4% | 3% | .24 |
PTEN | 12 | 6% | 1% | 10% | 0% | .009 |
TP53 | 8 | 1% | 1% | 9% | 0% | .006 |