Table 5 Mutations in methylation sub-types a
From: Genomic investigation of etiologic heterogeneity: methodologic challenges
Gene | # Cases | Sub-type 1 | Sub-type 2 | Sub-type 3 | Sub-type 4 | p-value |
|---|---|---|---|---|---|---|
n = 80 | n = 83 | n = 70 | n = 93 | |||
VHL | 162 | 48% | 61% | 45% | 64% | .04 |
PBRM1 | 97 | 12% | 31% | 31% | 55% | <.001 |
SETD2 | 36 | 5% | 6% | 23% | 15% | .003 |
BAP1 | 33 | 11% | 4% | 25% | 7% | <.001 |
MTOR | 22 | 8% | 6% | 6% | 10% | .80 |
ADAM6 | 22 | 5% | 7% | 5% | 12% | .30 |
MST1P2 | 22 | 9% | 10% | 8% | 4% | .41 |
PDE4DIP | 18 | 7% | 6% | 6% | 6% | 1.00 |
KDM5C | 17 | 7% | 3% | 5% | 8% | .50 |
PTEN | 12 | 8% | 0% | 5% | 4% | .11 |
TP53 | 8 | 4% | 0% | 8% | 1% | .04 |