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Table 2 Reported proportions of categorical change from baseline at month 1 in BCVA in patients with BRVO and CRVO on dexamethasone and sham

From: Indirect comparisons of ranibizumab and dexamethasone in macular oedema secondary to retinal vein occlusion

 

BRVO

CRVO

Improvement or worsening at month 1

Dexamethasone (n1 = 291)

Sham (n2 = 279)

Relative risk* (95% CI)

Dexamethasone (n1 = 136)

Sham (n2 = 147)

Relative risk* (95% CI)

Gain ≥15 letters

0.213

0.079

2.70 (1.71, 4.27)

0.213

0.068

3.13 (1.59, 6.19)

Gain ≥5 and <15 letters

0.474

0.369

1.28 (1.06, 1.56)

0.412

0.245

1.68 (1.19, 2.38)

Loss <5 letters and gain <5 letters

0.258

0.441

0.58 (0.46, 0.74)

0.301

0.483

0.62 (0.46, 0.85)

Loss ≥5 letters and <15 letters

0.055

0.097

0.57 (0.31, 1.03)

0.037

0.136

0.27 (0.10, 0.70)

Loss ≥15 letters

0.000

0.014

0.000 (0.00, 0.00)

0.037

0.068

0.54 (0.19, 1.54)

Gain ≥10 letters

0.426

0.201

2.12 (1.62, 2.78)

0.456

0.122

3.74 (2.33, 5.96)

Mean improvement (letters)

8.5

3.8

 

7.2

0.4

 

SD improvement§

7.916

7.916

 

10.721

10.721

 
  1. Source: GENEVA, 2010; NICE manufacturer submission [10].
  2. *Ratio of treatment (dexamethasone) probability to control (Sham) probability. § Estimated from reported limits on change BCVA.
  3. Mean improvements were reported up to only 1 decimal place.
  4. Confidence intervals for relative risk calculated via delta method and reported patient numbers.