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Table 8 Parameter estimation and estimated mean time-to-onset for 64 cases of lymphoma that occurred after anti TNF- α treatment

From: Estimating time-to-onset of adverse drug reactions from spontaneous reporting databases

 

Naive estimator

TBE

Distribution

λ ̂

β ̂

Expectation (weeks)

λ ̂

β ̂

p ̂

Expectation (weeks)

Exponential

0.00739

-

135

0.00172

-

0.60

581

[264,7528]*

Weibull

0.00666

1.55

135

0.00468

1.49

0.98

193

[150,432]*

Log-logistic

0.00890

2.06

171

0.00408

1.53

0.76

567

[207,1.8 ×1012]*

  1. *95% confidence intervals calculated using BCa simple bootstrap method based on 5000 replicates. p ̂ =F( t ∗ =529;( λ ̂ TBE , β ̂ TBE )).
  2. Abbreviations : TBE truncation-based estimator.
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BMC Medical Research Methodology

ISSN: 1471-2288

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