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Table 8 Parameter estimation and estimated mean time-to-onset for 64 cases of lymphoma that occurred after anti TNF- α treatment

From: Estimating time-to-onset of adverse drug reactions from spontaneous reporting databases

  Naive estimator TBE
Distribution λ ̂ β ̂ Expectation (weeks) λ ̂ β ̂ p ̂ Expectation (weeks)
Exponential 0.00739 - 135 0.00172 - 0.60 581 [264,7528]*
Weibull 0.00666 1.55 135 0.00468 1.49 0.98 193 [150,432]*
Log-logistic 0.00890 2.06 171 0.00408 1.53 0.76 567 [207,1.8 ×1012]*
  1. *95% confidence intervals calculated using BCa simple bootstrap method based on 5000 replicates. p ̂ =F( t =529;( λ ̂ TBE , β ̂ TBE )).
  2. Abbreviations : TBE truncation-based estimator.
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