Skip to main content

Advertisement

Table 1 Analysis results from the MIST2 dataset

From: Accounting for centre-effects in multicentre trials with a binary outcome – when, why, and how?

  tPA vs placebo (n = 98) DNase vs placebo (n = 94) tPA+DNase vs placebo (n = 98)
Unadjusted for centre-effects    
  Patients included – no. (%) 98 (100) 94 (100) 98 (100)
  Odds ratio (95% CI) 0.42 (0.09 to 1.87) 2.72 (0.88 to 8.42) 0.23 (0.04 to 1.29)
  P-value 0.25 0.08 0.10
Fixed-effects    
  Patients included – no. (%) 66 (67) 80 (85) 81 (83)
  Odds ratio (95% CI) 0.54 (0.12 to 2.56) 3.34 (1.01 to 11.00) 0.24 (0.04 to 1.36)
  P-value 0.44 0.048 0.11
Random-effects    
  Patients included – no. (%) 98 (100) 94 (100) 98 (100)
  Odds ratio (95% CI) 0.42 (0.09 to 1.87) 2.72 (0.88 to 8.42) 0.23 (0.04 to 1.29)
  P-value 0.25 0.08 0.10
GEE*    
  Patients included – no. (%) 98 (100) 94 (100) 98 (100)
  Odds ratio (95% CI) 0.33 (0.06 to 1.75) 2.57 (0.76 to 8.66) 0.18 (0.03 to 1.19)
  P-value 0.19 0.13 0.08
Mantel-Haenszel    
  Patients included – no. (%) 30 (31) 45 (48) 35 (36)
  Odds ratio (95% CI) 0.34 (0.05 to 2.15) 3.59 (0.99 to 13.03) 0.21 (0.02 to 1.98)
  P-value 0.27 0.04 0.13
  1. *Convergence was not achieved.