Skip to main content

Advertisement

Table 2 Number (%) of statistically significant Cochrane meta-analyses according to the DerSimonian-Laird and Hartung-Knapp-Sidik-Jonkman methods

From: The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method

Outcome Selected meta-analyses N DL test significant HKSJ test significant HKSJ test not significant, positive DL test
Continuous All 255 130 (51.0) 102 (40.0) 31/130 (23.8)
  Ratio > 5, < = 5 studies 46 22 (47.8) 13 (28.3) 13/22 (59.1)
Dichotomous All 434 185 (42.6) 147 (33.9) 48/185 (25.9)
  Ratio > 5, < = 5 studies 76 28 (36.8) 15 (19.7) 14/28 (50.0)
  1. All: all meta-analyses with a continuous or dichotomous outcome that fulfilled the following criteria: the first meta-analysis in a review in the Cochrane Database for Systematic Reviews Issues of 2012, based on at least three studies. Ratio >5, < = 5 studies: a selection of these meta-analyses based on at most five studies, where the ratio of the largest vs. the smallest trial size was > 5. DL: DerSimonian & Laird meta-analysis method. HKSJ: Hartung-Knapp-Sidik-Jonkman meta-analysis method. DL test significant: DL p-value <0.05; HKSJ test significant: HKSJ p-value < 0.05. Note that in a few cases the HKSJ test was significant when the DL test was not.