From: Developing and validating risk prediction models in an individual participant data meta-analysis
First author and year of publication | First author location | Research aims | Baseline condition of participants | Main outcome(s) of interest for prediction | Approach to identify relevant studies | Number of studies providing IPD (Number requested) |
---|---|---|---|---|---|---|
Pagliaro (1994)[29] | Italy | To identify predictors of short-term and sustained Alanine transaminase (ALT) normalization after interferon treatment in adult patients with hepatitis C | Adult patients with transfusion-related or community-acquired | Short term and sustained response (ALT normalization) | Collaborative group | 2 (NA) |
Heffner (2000)[26] | USA | To determine the predictive accuracy of pH for identifying patients with malignant pleural effusions who will fail pleurodesis | Patients with malignant pleural effusions | Failure of pleurodesis | Literature review | 6 (12) |
Raboud (2000)[30] | Canada | To determine the ability of intermediate plasma viral load (pVL) measurements to predict virologic outcome at 52 weeks of follow-up in clinical trials of antiretroviral therapy | Patients within a particular range of CD4 cell counts, naive to antiretroviral therapy and not been previously diagnosed with AIDS | Virologic outcome at 52 weeks of follow-up | Collaborative group | 3 (NA) |
Terwee (2000)[34] | Netherlands | To develop a prognostic tool for patients with unresectable pancreatic cancer to distinguish between low or high probabilities of survival 3 to 9 months after diagnosis. | Patients diagnosed with pancreatic cancer | Overall survival | Literature review | 8 (15) |
Chau (2004)[24] | United Kingdom | To identify baseline patient- or tumour-related prognostic factors; and to assess whether pre-treatment quality of life predicts survival in patients with locally advanced or metastatic esophago-gastric cancer. | Patients with histologically confirmed inoperable adenocarcinoma, squamous cell carcinoma, or undifferentiated carcinoma of the oesophagus, esophago-gastric junction, or stomach | Overall survival | Collaborative group | 3 (NA) |
Horn (2005)[27] | Netherlands | Investigate if transcranial doppler monitoring for micro embolic signals, directly after carotid endarterectomy (CEA) identifies patients at risk of developing ischaemic complications. | Carotid endarterectomy patients | Cerebral ischaemic complications, defined as new neurological deficits within 1st week after CEA | Literature review | 7 (10) |
Nieder (2005)[28] | Germany | Identifying the predictive value of biologically effective dose as function of the risk of myelopathy | Patients with spinal cord retreatment | Development of radiation myelopathy | Literature review | 8 (8) |
Asia pacific group (2006)[23] | Australia | To investigate the generalisability of current definitions of the metabolic syndrome in Asia-Pacific populations, and assess the prognostic value of metabolic risk factors to discriminate fatal coronary heart disease (CHD) risk | Healthy patients aged 30–75 | Fatal CHD within 10 years | Collaborative group | 26 (NA) |
Sylvester (2006)[33] | Belgium | To predict a superficial bladder cancer patient’s probability of recurrence and progression at one and five years | Stage Ta, T1, and Tis bladder cancer patients who have undergone transurethral resection | Time to first recurrence (disease-free interval) and time to progression to muscle invasive disease | Collaborative group | 7 (NA) |
Noordzij (2007)[5] | USA | Early prediction of hypocalcaemia after thyroidectomy using parathyroid hormone | Patients undergoing thyroidectomy | Postoperative symptomatic hypocalcaemia | Literature review | 9 (15) |
Rovers (2007)[31] | Netherlands | To determine the predictors of a prolonged course for children with acute otitis media (AOM) to discriminate between children with and without poor outcomes | Children with AOM | A prolonged course of AOM (pain and/or fever at 3 to 7 days) | Literature review | 6 (10) |
Schaich (2007)[32] | Germany | To identify prognostic indicators in acute myeloid leukaemia (AML) to provide a new prognostic model for risk stratification of AML patients | AML patients | Overall survival and relapse-free survival | Collaborative group | 8 (NA) |
Fowkes (2008)[25] | United Kingdom | To determine if the ankle brachial index provides information on the risk of cardiovascular events and mortality independently of the Framingham risk score and can improve risk prediction | Participants of any age and sex derived from a general population | Total and cardiovascular mortality | Literature review | 16 (20) |
Steyerberg (2008)[18] | Netherlands | To develop prediction model for predicting unfavourable outcome according to the glasgow outcome scale (GOS) at 6 months after traumatic brain injury (TBI) | Patients with moderate or severe TBI (with GOS > = 12) | 6-months mortality and unfavourable outcomes defined by 6 months GOS | Collaborative group | 11 (NA) |
Yap (2008)[35] | United Kingdom | To design a prognostic indicator using demographic information to select patients at risk of dying after myocardial infarction (MI) | Patients at day 45 post-MI up to 2 years | All-cause, arrhythmic and non-arrhythmic cardiac mortality within 2 years | Not stated | 4 (unknown) |