Lighting
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Light exposure varies with respect to rack location and position of cages within the rack
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[27, 28]
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Small differences in light intensity have been associated with reproductive and behavioral changes
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[27, 29, 30]
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There can be a four-fold difference in light intensity between cages at the top or bottom of a rack
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[18]
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Temperature
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Temperature in animal room at 1.5 m can be 3-4˚C higher than at 0.5 m
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[18]
|
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Cage temperature varies with group size
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[18]
|
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Cage temperature varies with height of placement within the rack (top rack 5˚C warmer than bottom rack)
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[18, 31, 32]
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Small changes in temperature can influence metabolic rates and toxicity
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[27, 31, 33]
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Random outcome assessment
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Circadian rhythm
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Periodic/circadian variations in lipid metabolism, neurotransmitter levels, pharmacokinetic effects, etc.
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[34–37]
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