|
Lighting
|
Light exposure varies with respect to rack location and position of cages within the rack
|
[27, 28]
|
| |
Small differences in light intensity have been associated with reproductive and behavioral changes
|
[27, 29, 30]
|
| |
There can be a four-fold difference in light intensity between cages at the top or bottom of a rack
|
[18]
|
|
Temperature
|
Temperature in animal room at 1.5 m can be 3-4˚C higher than at 0.5 m
|
[18]
|
| |
Cage temperature varies with group size
|
[18]
|
| |
Cage temperature varies with height of placement within the rack (top rack 5˚C warmer than bottom rack)
|
[18, 31, 32]
|
| |
Small changes in temperature can influence metabolic rates and toxicity
|
[27, 31, 33]
|
|
Random outcome assessment
|
|
Circadian rhythm
|
Periodic/circadian variations in lipid metabolism, neurotransmitter levels, pharmacokinetic effects, etc.
|
[34–37]
|
