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Table 3 Increments (positive values) and decrements (negative values) of power (%) for ANCOVA, ANOVA and CSA relative to a nominal power of 80% and conditional upon levels of baseline imbalance and ZY correlation

From: Bias, precision and statistical power of analysis of covariance in the analysis of randomized trials with baseline imbalance: a simulation study

 

Z′ T –Z′ C

Treatment effect

 

0.2

0.5

0.8

ZYcorrelation

ZYcorrelation

ZYcorrelation

Analysis

 

0

0.1

0.3

0.5

0.7

0.9

0

0.1

0.3

0.5

0.7

0.9

0

0.1

0.3

0.5

0.7

0.9

ANCOVA

−1.96

−1.00

5.10

13.60

>19.9

>19.9

>19.9

−1.70

4.10

14.90

18.60

>19.9

>19.9

−1.40

1.20

10.00

16.40

19.90

>19.9

 

−1.64

−1.00

4.50

11.90

19.90

>19.9

>19.9

−0.90

3.80

13.90

18.40

>19.9

>19.9

–.80

.70

9.50

15.80

19.90

>19.9

 

−1.28

−0.70

3.60

10.40

18.90

>19.9

>19.9

−0.90

3.10

12.10

17.30

>19.9

>19.9

–.10

.90

8.80

15.30

19.90

>19.9

 

0.00

−0.40

0.60

2.00

10.50

17.20

>19.9

−0.10

−0.30

4.10

9.90

17.40

>19.9

.00

−1.30

1.20

7.60

14.10

>19.9

 

1.28

−0.50

−1.80

−6.30

−7.00

−2.90

15.10

−0.20

−4.30

−8.50

−10.20

−4.30

16.10

−1.50

−6.30

−11.00

−12.40

−7.50

13.20

 

1.64

−0.70

−2.80

−11.10

−14.80

−15.20

3.80

−0.50

−6.00

−12.30

−16.90

−15.60

5.40

−2.30

−7.90

−17.10

−21.40

−20.30

4.10

 

1.96

−0.70

−3.70

−15.40

−21.20

−26.50

−12.90

−0.80

−7.30

−15.30

−23.70

−28.00

−13.30

−3.60

−9.90

−21.00

−28.30

−31.90

−16.30

CSA

−1.96

11.50

14.70

17.70

>19.9

>19.9

>19.90

10.90

17.10

19.10

19.60

>19.9

>19.9

12.80

13.70

16.00

19.90

>19.9

>19.9

 

−1.64

7.70

11.40

15.80

>19.9

>19.9

>19.90

7.30

9.70

16.80

19.00

>19.9

>19.9

9.40

10.60

14.20

19.80

19.90

>19.9

 

−1.28

2.40

6.50

12.50

19.90

>19.9

>19.90

1.10

4.80

13.40

18.50

>19.9

>19.9

3.10

5.50

11.80

16.00

19.90

>19.9

 

0.00

−26.60

−22.20

−11.60

2.00

15.40

>19.90

−27.70

−23.50

−13.10

–.30

15.10

>19.9

−28.50

−26.40

−15.80

−1.40

12.00

>19.9

 

1.28

−60.00

−58.30

−52.90

−44.30

−26.60

10.30

−59.20

−57.70

−52.30

−45.40

−28.80

12.80

−58.40

−57.60

−54.30

−46.80

−30.20

11.40

 

1.64

−67.20

−65.30

−62.60

−56.50

−46.90

−6.10

−65.70

−64.50

−61.00

−56.00

−45.50

−6.00

−65.40

−65.20

−61.80

−57.30

−47.10

−5.60

 

1.96

−71.40

−71.00

−68.70

−66.20

−59.30

−29.50

−69.60

−68.90

−67.30

−64.50

−57.60

−31.60

−69.80

−69.40

−67.90

−64.60

−59.00

−29.80

ANOVA

−1.96

−0.60

−0.80

0.20

−1.30

−0.30

0.80

−0.30

0.30

−0.70

0.20

0.10

0.10

2.00

1.00

1.70

1.90

2.80

2.60

 

−1.64

−0.60

−0.80

0.20

−1.30

−0.30

0.80

−0.30

0.30

−0.70

0.20

0.10

0.10

2.00

1.00

1.70

1.90

2.80

2.60

 

−1.28

−0.60

−0.80

0.20

−1.30

−0.30

0.80

−0.30

0.30

−0.70

0.20

0.10

0.10

2.00

1.00

1.70

1.90

2.80

2.60

 

0.00

−0.60

−0.80

0.20

−1.30

−0.30

0.80

−0.30

0.30

−0.70

0.20

0.10

0.10

2.00

1.00

1.70

1.90

2.80

2.60

 

1.28

−0.60

−0.80

0.20

−1.30

−0.30

0.80

−0.30

0.30

−0.70

0.20

0.10

0.10

2.00

1.00

1.70

1.90

2.80

2.60

 

1.64

−0.60

−0.80

0.20

−1.30

−0.30

0.80

−0.30

0.30

−0.70

0.20

0.10

0.10

2.00

1.00

1.70

1.90

2.80

2.60

 

1.96

−0.60

−0.80

0.20

−1.30

−0.30

0.80

−0.30

0.30

−0.70

0.20

0.10

0.10

2.00

1.00

1.70

1.90

2.80

2.60

  1. Maximum increment is given as >19.9 since this would represent a conditional power in excess of 99.9%. Increments/decrements in power for ANOVA are due to random variation of the simulated dataset around the nominal 80% power.