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Table 1 True marginal probability of toxicity, marginal probability of efficacy and D ( z ) for each dose level

From: Evaluating the performance of copula models in phase I-II clinical trials under model misspecification

Scenario     Dose  
   1 2 3 4
1 P(Toxicity) 0.05 0.12 0.27 0.50
  P(Efficacy) 0.38 0.55 0.71 0.83
  D(z) -0.38 -0.03 0.16 -0.07
2 P(Toxicity) 0.38 0.52 0.67 0.79
  P(Efficacy) 0.77 0.82 0.86 0.89
  D(z) 0.08 -0.11 -0.38 -0.6
3 P(Toxicity) 0.02 0.07 0.15 0.31
  P(Efficacy) 0.12 0.25 0.45 0.67
  D(z) -0.96 -0.67 -0.26 0.04
4 P(Toxicity) 0.05 0.11 0.25 0.46
  P(Efficacy) 0.18 0.55 0.79 0.86
  D(z) -0.82 -0.02 0.32 0.03
5 P(Toxicity) 0.03 0.08 0.18 0.38
  P(Efficacy) 0.18 0.25 0.33 0.43
  D(z) -0.82 -0.67 -0.53 -0.48
  1. Optimal dose is in bold.