Evaluating the performance of copula models in phase I-II clinical trials under model misspecification

Table 7 Average posterior mean (standard deviation) for the correlation parameters, ψ _k , k = 1,2, when 11 subjects are treated at each dose level

Braun model	Scenario 1	Scenario 2	Scenario 3	Scenario 4	Scenario 5
ψ ₁=0.5	0.535	0.546	0.531	0.546	0.495
	(0.023)	(0.021)	(0.024)	(0.024)	(0.025)
ψ ₁=0.7	0.659	0.668	0.656	0.660	0.643
	(0.020)	(0.018)	(0.021)	(0.019)	(0.021)
ψ ₁=0.9	0.784	0.824	0.792	0.777	0.811
	(0.010)	(0.008)	(0.012)	(0.010)	(0.010)
Gumbel model	Scenario 1	Scenario 2	Scenario 3	Scenario 4	Scenario 5
ψ ₂=0.0	-0.001	-0.003	0.005	-0.005	-0.002
	(0.075)	(0.081)	(0.067)	(0.067)	(0.072)
ψ ₂=0.4	0.115	0.105	0.119	0.091	0.118
	(0.073)	(0.076)	(0.063)	(0.06)	(0.072)
ψ ₂=0.8	0.225	0.244	0.194	0.212	0.219
	(0.062)	(0.065)	(0.06)	(0.057)	(0.061)

Data are generated assuming the correct model and specified true correlation between Y _T and Y _E (ψ _k).

ISSN: 1471-2288