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Table 7 Average posterior mean (standard deviation) for the correlation parameters, ψ k , k = 1,2, when 11 subjects are treated at each dose level

From: Evaluating the performance of copula models in phase I-II clinical trials under model misspecification

Braun model Scenario 1 Scenario 2 Scenario 3 Scenario 4 Scenario 5
ψ 1=0.5 0.535 0.546 0.531 0.546 0.495
  (0.023) (0.021) (0.024) (0.024) (0.025)
ψ 1=0.7 0.659 0.668 0.656 0.660 0.643
  (0.020) (0.018) (0.021) (0.019) (0.021)
ψ 1=0.9 0.784 0.824 0.792 0.777 0.811
  (0.010) (0.008) (0.012) (0.010) (0.010)
Gumbel model Scenario 1 Scenario 2 Scenario 3 Scenario 4 Scenario 5
ψ 2=0.0 -0.001 -0.003 0.005 -0.005 -0.002
  (0.075) (0.081) (0.067) (0.067) (0.072)
ψ 2=0.4 0.115 0.105 0.119 0.091 0.118
  (0.073) (0.076) (0.063) (0.06) (0.072)
ψ 2=0.8 0.225 0.244 0.194 0.212 0.219
  (0.062) (0.065) (0.06) (0.057) (0.061)
  1. Data are generated assuming the correct model and specified true correlation between Y T and Y E (ψ k ).