Accuracy of T2 | Parameter value | AUC for T1 and T2 | AUC for T1 | AUC difference | IDI in events | IDI in non events | IDI* | |
---|---|---|---|---|---|---|---|---|
1) Higher sensitivity | S2 = 80, C2 = 90 | True | 0.93 | 0.80 | 0.13 | 0.16 | 0.07 | 0.23 |
Estimated | 0.93 (0.91, 0.95) | 0.80 (0.79, 0.80) | 0.13 (0.11, 0.15) | 0.17 (0.12, 0.22) | 0.07 (0.05, 0.10) | 0.25 (0.18, 0.32) | ||
2) Higher specificity | S2 = 70, C2 = 95 | True | 0.92 | 0.80 | 0.12 | 0.16 | 0.07 | 0.23 |
Estimated | 0.94 (0.91. 0.96) | 0.81 (0.80, 0.83) | 0.12 (0.11, 0.14) | 0.17 (0.12, 0.22) | 0.07 (0.05, 0.09) | 0.28 (0.22, 0.34) | ||
3) Lower sensitivity | S2 = 60, C2 = 90 | True | 0.88 | 0.80 | 0.09 | 0.09 | 0.04 | 0.12 |
Estimated | 0.89 (0.87, 0.91) | 0.80 (0.79, 0.80) | 0.09 (0.07, 0.11) | 0.10 (0.06, 0.14) | 0.04 (0.03, 0.06) | 0.14 (0.09, 0.20) | ||
4) Lower specificity | S2 = 70, C2 = 80 | True | 0.88 | 0.80 | 0.09 | 0.07 | 0.03 | 0.10 |
Estimated | 0.89 (0.87, 0.91) | 0.80 (0.79, 0.80) | 0.09 (0.07, 0.11) | 0.08 (0.05, 0.12) | 0.03 (0.02, 0.05) | 0.11 (0.07, 0.17) | ||
5) Both better | S2 = 80, C2 = 95 | True | 0.94 | 0.80 | 0.14 | 0.21 | 0.09 | 0.30 |
Estimated | 0.94 (0.92, 0.96) | 0.80 (0.80, 0.81) | 0.14 (0.12, 0.17) | 0.21 (0.16, 0.26) | 0.09 (0.07, 0.11) | 0.30 (0.23, 0.36) | ||
6) Both worse | S2 = 60, C2 = 80 | True | 0.87 | 0.80 | 0.07 | 0.05 | 0.02 | 0.07 |
Estimated | 0.87 (0.85, 0.89) | 0.80 (0.79, 0.80) | 0.07 (0.05, 0.09) | 0.05 (0.03, 0.08) | 0.02 (0.01, 0.04) | 0.07 (0.04, 0.12) | ||
7) No better | S2 = 70, C2 = 90 | True | 0.90 | 0.80 | 0.10 | 0.12 | 0.05 | 0.17 |
Estimated | 0.91 (0.89, 0.94) | 0.80 (0.79, 0.80) | 0.11 (0.09, 0.14) | 0.13 (0.09, 0.19) | 0.06 (0.04, 0.08) | 0.19 (0.13, 0.27) | ||
8) No value | S2 = 70, C2 = 30 | True | 0.80 | 0.80 | -0.00 | -0.00 | 0.00 | -0.00 |
Estimated | 0.81 (0.80, 0.82) | 0.80 (0.79, 0.80) | 0.01 (0.006, 0.02) | 0.001 (0, 0.004) | <0.001 (0, 0.002) | 0.002 (0.001, 0.006) |