Table 4 Sensitivity to prior distribution for the case when both sensitivity and specificity of the second test are better than the first test (true values are S 1  = 0.7, C 1  = 0.9)
Conditional Independence Model | ||||||
|---|---|---|---|---|---|---|
Prior information on T1 sensitivity and specificity | IDI (True value 0.3) | AUCdiff(True value 0.14) | ||||
Bias | Length | Coverage | Bias | Length | Coverage | |
Informative priors centered at true values* | 0.001 | 0.43 | 1 | -0.003 | 0.14 | 0.99 |
Degenerate priors at true values: S1 = 0.7, C1 = 0.9 | 0.006 | 0.19 | 0.95 | -0.001 | 0.07 | 1 |
Degenerate priors, but not at true values: S1 = 0.8, C1 = 0.925 | -0.17 | 0.08 | 0 | -0.07 | 0.04 | 0 |
Informative priors covering but not centered on true values†(centered on S1 = 0.8, C1 = 0.925) | -0.16 | 0.42 | 0.99 | -0.07 | 0.15 | 1 |