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Table 2 Change in measures with addition of systolic blood pressure to models predicting cardiovascular disease for men and women

From: An assessment of the relationship between clinical utility and predictive ability measures and the impact of mean risk in the population

 

Men

  

Women

  
 

Base Model

Base Model + SBP

Difference

Base Model

Base Model + SBP

Difference (95% CI)

Sensitivity

0.575

0.585

0.010 (-0.17, 0.033)

0.280

0.344

0.064 (0.006, 0.099)

Specificity

0.729

0.734

0.005 (-0.003, 0.016)

0.921

0.909

-0.013 (-0.020, -0.003)

c-binary

0.652

0.655

0.008 (-005, 0.018)

0.601

0.626

0.025 (0.000, 0.041)

c-statistic

0.751

0.758

0.007 (0.003, 0.012)

0.766

0.782

0.016 (0.009, 0.024)

NRI binary*

  

0.015 (-0.009, 0.036)

  

0.051 (0.000, 0.082)

NRI continuous*

  

0.170 (0.071, 0.267)

  

0.306 (0.176, 0.419)

NRI categorical*

  

0.028 (-0.009, 0.063)

  

0.091(0.010, 0.129)

Net benefit difference (per 1000 evaluated)

44.0

47.5

3.5 (-1.6, 7.7)

8.7

12.1

3.3 (-1.3, 6.4)

Event Free Life Years difference (per 1000 evaluated)

32.1

34.1

2.0 (-1.8, 5.4)

3.8

7.5

3.6 (-0.4, 6.3)

  1. Abbreviation: SBP systolic blood pressure.
  2. *There are no separate NRI measures for the baseline and the expanded model. They are calculated as an overall measure comparing two models.