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Table 2 Multivariable Cox regression analysis for overall survival in patients with advanced ovarian cancer

From: Mediation analysis of the relationship between institutional research activity and patient survival

Variable N Events HR 95% CI
Research activity     
    Non-trial hospital 133 81 1 Reference
    Trial hospital 219 103 0.58 [0.42; 0.79]
Age     
    Continuous (5 years) 352 184 1.24 [1.14; 1.34]
Performance status     
    ECOG 0/1 267 118 1 Reference
    ECOG > 1 85 66 2.02 [1.38; 2.96]
Ascites     
    ≤ 500 ml 172 74 1 Reference
    > 500 ml 180 110 1.77 [1.23; 2.53]
Comorbidity     
    None 257 116 1 Reference
    Present 95 68 1.46 [1.08; 1.97]
Histology     
    Other 89 40 1 Reference
    Serous 263 144 1.29 [0.85; 1.94]
Grade     
    G 1/2 166 81 1 Reference
    G 3/4 186 103 1.10 [0.80; 1.50]