Table 2 Multivariable Cox regression analysis for overall survival in patients with advanced ovarian cancer
From: Mediation analysis of the relationship between institutional research activity and patient survival
Variable | N | Events | HR | 95% CI |
|---|---|---|---|---|
Research activity | ||||
Non-trial hospital | 133 | 81 | 1 | Reference |
Trial hospital | 219 | 103 | 0.58 | [0.42; 0.79] |
Age | ||||
Continuous (5 years) | 352 | 184 | 1.24 | [1.14; 1.34] |
Performance status | ||||
ECOG 0/1 | 267 | 118 | 1 | Reference |
ECOG > 1 | 85 | 66 | 2.02 | [1.38; 2.96] |
Ascites | ||||
≤ 500 ml | 172 | 74 | 1 | Reference |
> 500 ml | 180 | 110 | 1.77 | [1.23; 2.53] |
Comorbidity | ||||
None | 257 | 116 | 1 | Reference |
Present | 95 | 68 | 1.46 | [1.08; 1.97] |
Histology | ||||
Other | 89 | 40 | 1 | Reference |
Serous | 263 | 144 | 1.29 | [0.85; 1.94] |
Grade | ||||
G 1/2 | 166 | 81 | 1 | Reference |
G 3/4 | 186 | 103 | 1.10 | [0.80; 1.50] |