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Table 1 Event times generated according to a Cox-exponential model with a confounder X and an exposure status Z

From: Model-based estimation of measures of association for time-to-event outcomes

  BIAS MSE  
  PV PV Cox PV PV Cox
  (Z td) (Z const) CGPM (Z td) (Z const) CGPM
200 -0.0112 -0.0966 -0.0170 0.0756 0.1042 0.0580
400 -0.0047 -0.0681 -0.0145 0.0701 0.0785 0.0523
600 -0.0081 -0.0034 -0.0094 0.0528 0.0392 0.0376
  Width Coverage  
  PV PV Cox PV PV Cox
  (Z td) (Z const) CGPM (Z td) (Z const) CGPM
200 0.2857 0.1527 0.2143 0.9430 0.3150 0.9480
400 0.2791 0.1527 0.1926 0.9560 0.5830 0.9340
600 0.1949 0.1527 0.1418 0.9350 0.9400 0.9320
  1. CGPM was adopted using the Cox proportional hazard regression model. PV model was adopted with identity link. Pseudo times were fixed at quantiles 5%, 25%, 50%, 75%, 95% of the failure time distribution. The Z covariate was inserted in the PV model with an interaction with the baseline risk function modelled with a restricted cubic spline with 3 knots (Z td) giving an estimated risk difference varying through follow-up time, RD(t), and without time-dependence to estimate a constant RD through follow-up time between the first and the last pseudo-times (Z const).