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Figure 2 | BMC Medical Research Methodology

Figure 2

From: Optimal likelihood-ratio multiple testing with application to Alzheimer’s disease and questionable dementia

Figure 2

Brain regions with significantly lower FDG uptake in probable AD compared to NC. Regions with lower FDG uptake in probable AD are displayed. The left hemisphere is shown as a 3D volume rendering. The reduction in the FDG uptake in the temporal, parietal, and posterior prefrontal regions was commonly found in the LR-FDR and BH-FDR methods. Extensive hypometabolic areas extending to posterior prefrontal were detected with the LR-FDR one-sided and two-sided tests. The color bar range from minimum to maximum significance level denotes the significance of the likelihood ratio in both LR-FDR methods and of the p-value in BH-FDR method. (AD: Alzheimer’s disease; FDR: False discovery rate; LR-FDR: Likelihood ratio false discovery rate; NC: Normal controls).

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BMC Medical Research Methodology

ISSN: 1471-2288

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