Table 5 Marginal model and random-effects models analysing the influence of time and age
Marginal model GEE | Random model likelihood integration | |||||
|---|---|---|---|---|---|---|
Estimate | SE | p value | Estimate | SE | p value | |
Intercept | -1.83 | 0.12 | < 0.0001 | -3.61 | 0.25 | < 0.0001 |
Time (years) | 0.12 | 0.03 | < 0.0001 | 0.17 | 0.06 | 0.002 |
Age at baseline* | 0.09 | 0.02 | < 0.0001 | 0.16 | 0.03 | < 0.0001 |
Age* × time | 0.01 | 0.004 | 0.003 | 0.04 | 0.009 | < 0.0001 |
Baseline disability | 1.54 | 0.10 | < 0.0001 | 3.18 | 0.22 | < 0.0001 |
Death during the study | 0.68 | 0.12 | < 0.0001 | 1.36 | 0.26 | < 0.0001 |
Random intercept variance | - | - | - | 7.25 | 0.68 | < 0.0001 |
Random slope variance | - | - | - | 0.18 | 0.04 | < 0.0001 |