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Table 2 Adjusted P values corresponding to a raw P = 0.05 for binomial and continuous outcomes, according to the number of matched-pairs tested. After Armitage et al. [16]

From: Interim analyses of data as they accumulate in laboratory experimentation

Number of pairs

Nominal critical

Pvalue

Adjusted actual Pvalue (P')

  

(binomial)

(continuous normal)

1

0.050

0.050

0.050

10

0.050

0.055

0.194

20

0.050

0.107

0.248

50

0.050

0.171

0.320

100

0.050

0.227

0.374