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Table 1 Sensitivity analyses for measured blood loss ≥ 1000 ml (severe post-partum haemorrhage, or SPPH)

From: The reporting of methods for reducing and detecting bias: an example from the WHO Misoprostol Third Stage of Labour equivalence randomised controlled trial

Assumed bias introduced in SPPH by unblinding due to shivering (mls) Group No. of women No. of cases % RR 95% CI
500 Misoprostol 9214 295 3.2 1.23 (1.04 to 1.45)
  Oxytocin 9228 241 2.6   
400 Misoprostol 9214 307 3.3 1.27 (1.07 to 1.49)
  Oxytocin 9228 243 2.6   
300 Misoprostol 9214 313 3.4 1.29 (1.09 to 1.52)
  Oxytocin 9228 243 2.6   
200 Misoprostol 9214 322 3.5 1.28 (1.09 to 1.51)
  Oxytocin 9228 251 2.7   
100 Misoprostol 9214 334 3.6 1.31 (1.11 to 1.53)
  Oxytocin 9228 256 2.8   
0 Misoprostol 9214 366 4.0 1.39 (1.19 to 1.63)
  Oxytocin 9228 263 2.9   
-100 Misoprostol 9214 401 4.4 1.50 (1.29 to 1.75)
  Oxytocin 9228 267 2.9   
-200 Misoprostol 9214 453 4.9 1.64 (1.41 to 1.90)
  Oxytocin 9228 277 3.0   
-300 Misoprostol 9214 499 5.42 1.74 (1.51 to 2.00)
  Oxytocin 9228 288 3.12   
-400 Misoprostol 9214 591 6.41 1.94 (1.70 to 2.22)
  Oxytocin 9228 305 3.31   
-500 Misoprostol 9214 688 7.47 2.10 (1.85 to 2.39)
  Oxytocin 9228 328 3.55