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Table 4 Characteristics of Optimal (for ETSL) Design Assuming Misspecification of Accrual

From: Design of Phase II cancer trials evaluating survival probabilities

  Scenario 1* Scenario 2* Scenario 3*
Actual/Anticipated Accrual α 1-β α 1 - β α 1 - β
0.25 .1 .512 .070 .687 .109 .924
0.50 .1 .711 .082 .800 .106 .918
1.00 .1 .900 .100 .900 .100 .900
1.50 .1 .963 .114 .934 .092 .863
2.00 .1 .986 .115 .970 .079 .779
  1. * Scenario 1 – Analysis at t 1 and MTSL ; Scenario 2 – Analysis at t 1 and one year after t 1 or one year after accruing n patients, whichever is later; Scenario 3 – Analysis after accrual of n 1 patients and one year after accruing n patients.