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Table 6 Realized α and 1 - β using simulations of the optimal designs for testing H0: S(1) ≤ .35. Power is specified for S(1) = .5.

From: Design of Phase II cancer trials evaluating survival probabilities

  Desired α = .1, 1 - β = .9 Desired α = .05, 1 - β = .95
  ETSL EDA ETSL EDA
DA/x* α 1 - β α 1 - β α 1 - β α 1 - β
1.50 .103 .909 .100 .907 .049 .953 .043 .948
1.75 .104 .909 .114 .918 .049 .954 .045 .951
2 .126 .919 .089 .898 .050 .954 .051 .955
3 .092 .904 .116 .918 .045 .952 .059 .961
4 .092 .903 .091 .903 .045 .954 .048 .955