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Panel 1 Factors that determine the proper choice of a control intervention for a trial

From: Choosing a control intervention for a randomised clinical trial

• Existent knowledge concerning the relative efficacy of the proposed experimental and control interventions
• The dose (for drugs) and mechanism of control intervention application
• Appreciation of the range of interventions available for the condition being evaluated (drug versus non-drug therapies)
• Current medical practice in the setting in which the trial is conducted