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Table 1 Data from a cancer prevention trial for investigating assumptions of constant risk difference and relative risk when risk groups change.

From: The fallacy of enrolling only high-risk subjects in cancer prevention trials: Is there a "free lunch"?

   

Placebo group

Tamoxifen group

Variable

risk group

cancer

at risk

cancer

at risk

age at entry

1

≤ 49

68

10149

38

10045

 

2

50–59

50

7912

25

8040

 

3

>60

57

7719

26

7782

predicted risk

1

≤ 2.00%

35

6318

13

6311

 

2

2.01–3.01%

42

8108

29

8262

 

3

3.01–5.00%

43

7313

27

6959

 

4

≤ 5.01%

55

4142

20

4425

family risk

1

0

38

5891

17

5724

 

2

1

90

15000

46

15182

 

3

2

37

4263

20

4211

 

4

3

10

729

6

855

  1. Cancer is invasive breast cancer. Predicted risk is the 5-year predicted risk. Family risk is number of first degree relatives with breast cancer. Data are from Table 5 of [5] with number at risk computed by dividing number of breast cancers by reported breast cancer rate.