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Table 1 Data from a cancer prevention trial for investigating assumptions of constant risk difference and relative risk when risk groups change.

From: The fallacy of enrolling only high-risk subjects in cancer prevention trials: Is there a "free lunch"?

    Placebo group Tamoxifen group
Variable risk group cancer at risk cancer at risk
age at entry 1 ≤ 49 68 10149 38 10045
  2 50–59 50 7912 25 8040
  3 >60 57 7719 26 7782
predicted risk 1 ≤ 2.00% 35 6318 13 6311
  2 2.01–3.01% 42 8108 29 8262
  3 3.01–5.00% 43 7313 27 6959
  4 ≤ 5.01% 55 4142 20 4425
family risk 1 0 38 5891 17 5724
  2 1 90 15000 46 15182
  3 2 37 4263 20 4211
  4 3 10 729 6 855
  1. Cancer is invasive breast cancer. Predicted risk is the 5-year predicted risk. Family risk is number of first degree relatives with breast cancer. Data are from Table 5 of [5] with number at risk computed by dividing number of breast cancers by reported breast cancer rate.
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