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Table 1 Estimated accrual periods for a 360-participant, 10-center clinical trial.

From: Practical considerations for estimating clinical trial accrual periods: application to a multi-center effectiveness study

 

Unconditional Approacha

Conditional Ratesb

Poisson Processc,d

Poisson Process Variable Ratesc,e

Estimated Accrual Period (in months)

   Mean

18

23

23.2

42.6

   Standard Deviation

NA

NA

1.0

8.0

   Range

NA

NA

[20.1, 25.8]

[28.0, 84.0]

   75th Percentile

NA

NA

24.0

46.0

  1. a10 sites enrolling at a rate of 2 participants per month.
  2. bFor the conditional rate, the rate per month is illustrated in Figure 1.
  3. cBased on 500 simulation iterations
  4. dA rate of 2 participants per month with recruitment on 5 days a week
  5. eA rate uniformly distributed on [0,2] with recruitment on 5 days a week
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BMC Medical Research Methodology

ISSN: 1471-2288

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