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Table 1 ASN required to reach a conclusion under H0/H1, and when θ = θR/2 for the TT (R = 1), TT (R = 2), DTT (R = 1) and DTT (R = 2) and sample size for the SSD (R = 1) and SSD (R = 2), for different values of θR, β (α = 0.05) and n = 12.

From: Sequential boundaries approach in clinical trials with unequal allocation ratios

θR β SSD R = 1 SSD R = 2 TT(R = 1) TT(R = 2) DTT(R = 1) DTT(R = 2)
     ASN (H0/H1) ASN (θR/2) ASN (H0/H1) ASN (θR/2) ASN (H0/H1) ASN (θR/2) ASN (H0/H1) ASN (θR/2)
0.4 0.05 325 366 168/185 239 188/208 269 220/184 247 248/208 273
  0.1 263 296 135/164 191 152/184 215 179/165 199 201/185 224
0.5 0.05 208 234 108/120 155 122/134 173 143/120 159 160/135 179
  0.1 168 189 88/107 124 98/120 139 116/108 129 129/120 145
0.6 0.05 144 163 77/85 109 86/95 122 100/86 112 113/95 125
  0.1 117 131 62/76 87 69/85 98 82/76 90 92/85 102
0.7 0.05 106 119 57/64 81 64/71 91 75/64 84 84/72 93
  0.1 86 97 47/57 65 52/64 73 61/57 68 68/64 76
0.8 0.05 81 91 45/50 63 50/56 70 59/50 65 63/56 71
  0.1 66 74 37/45 51 41/50 57 46/44 51 53/50 59
0.9 0.05 64 72 36/41 51 40/45 56 46/41 51 52/45 58
  0.1 52 58 30/37 41 33/41 46 39/37 42 43/41 48
1.0 0.05 52 58 30/34 42 34/38 47 39/35 43 44/38 48
  0.1 42 47 25/31 34 28/34 38 29/29 32 36/34 39