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Table 1 Trial characteristics

From: The fading of reported effectiveness. A meta-analysis of randomised controlled trials

 

Pravastatin (n = 64)

Atorvastatin (n = 35)

 

Mean

± SD

Min.

Max.

Mean

± SD

Min.

Max.

Year of publication

1995.28

± 3.46

1990

2001

1999.40

± 1.82

1996

2001

Reported effect size*

-29.50

± 4.16

-19.0

-39.0

-36.07

± 3.70

-28.4

-44.2

Baseline†

205.62

± 47.78

134.4

344.0

198.05

± 35.05

143.0

340.3

Study size‡

595.77

± 1511.59

10

9014

328.71

± 686.64

22

3916

Treatment group§

EG: 56 (87%); CG: 8 (13%)

EG: 31 (89%); CG: 4 (11%)

 

Timolol (n = 75)

Latanoprost (n = 32)

 

Mean

± SD

Min.

Max.

Mean

± SD

Min.

Max.

Year of publication

1992.68

± 6.99

1978

2001

1999.06

± 2.00

1995

2001

Reported effect size

-6.55

± 1.56

-3.65

-11.3

-6.83

± 1.53

-3.5

-9.8

Baseline

25.94

± 2.49

20.8

38.7

24.07

± 2.13

19.3

28.2

Study size

197.96

± 249.59

12

1198

152.81

± 195.57

20

829

Treatment group

EG: 12 (16%); CG: 63 (84%)

EG: 29 (91%); CG: 3 (9%)

  1. Abbreviations: n, number of trials that met selection criteria; SD, standard deviation; EG, experimental group; CG, control group.
  2. * Unit of measurement for reported effect size: Change of intraocular pressure measured in mmHg (Timolol, Latanoprost), change in low-density lipoprotein cholesterol measured in % (Pravastatin, Atorvastatin).
  3. † Unit of measurement for baseline: Intraocular pressure measured in mmHg (Timolol, Latanoprost), low-density lipoprotein cholesterol measured in mg/dl (Pravastatin, Atorvastatin). To convert low-density lipoprotein cholesterol from milligrams per deciliter to millimoles per liter, multiply milligrams per deciliter by 0.0259.
  4. ‡ Unit of measurement for study size: Number of patients included in final analysis.
  5. § As the variable "treatment group" is either "experimental group" or "control group", exact frequencies and percentages are given.