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Table 1 Validation of statistical procedures. Validation of different statistical procedures using a simulated data-set. Results of Meta-DiSc (version 1.4) are compared with those obtained with metan (version 1.86) and metareg (version 1.06) STATA commands. Prior to the analyses, all four cells of all studies were added with 1/2 to avoid division by zero when computing some indices or standard errors. Meta-DiSc and STATA data-set are provided as additional files [see Additional file 1] and [see Additional file 2].

From: Meta-DiSc: a software for meta-analysis of test accuracy data

  Results
Procedure Meta-DiSc (version 1.4) STATA (ver 8.2)
Random Effect Model   
Pooled +ve LR 2.447 2.447
(95%(CI) (2.085 – 2.871) (2.085 – 2.871)
Tau-square 0.0932 0.0932
Cochrane-Q 139.71 139.71
Pooled -ve LR 0.157 0.157
(95%(CI) (0.095 – 0.257) (0.095 – 0.257)
Tau-square 0.4631 0.46357
Cochrane-Q 33.00 33.07
Fixed Effect Model   
Pooled +ve LR 2.330 2.330
(95%(CI) (2.208 – 2.459) (2.208 – 2.459)
Cochrane-Q 139.71 139.71
Pooled -ve LR 0.105 0.104
(95%(CI) (0.073 – 0.149) (0.073 – 0.148)
Cochrane-Q 33.00 33.07
Meta-Regression1   
Tau-Square 0.1141 0.1141
Constant coefficient (SE) 2.520 (0.8370) 2.5197 (0.83699)
S coefficient (SE) 0.330 (0.1912) 0.3304 (0.19123)
Covariable coefficient (SE) -0.036 (0.0904) -0.0355 (0.09041)
  1. (1) Meta-regression was weighted by the inverse of the variance of dOR and between study variance was estimated by REML.