Table 1 Relative bias of model parameters using non linear mixed models taking into account left-censored (undetectable) values (corrected) or not (crude) with simulated data. N = 20 patients, 1000 simulations, 14% left-censored measures in average.

V ₀

6.16 log₁₀ IU/mL

6.09

-1.1

6.16

-0.021

δ

0.40 day^-1

0.18

-55.2

0.40

+0.78

c

2.00 day^-1

1.10

-44.8

2.03

+1.5

ε

0.80

0.93

+15.8

0.79

-1.3

${\sigma }_{{\gamma }_0}^2$

0.49

0.59

+20.3

0.46

-6.4

${\sigma }_{{\gamma }_1}^2$

2.69

2.18

-18.8

2.31

-13.9

${\sigma }_e^2$

0.04

0.09

+133.2

0.039

-2.4