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Table 5 Summary of the validation with data set 1

From: Development and validation of MIX: comprehensive free software for meta-analysis of causal research data

  MIX STATA/CMA *
Items in odds ratio meta-analysis Results Results
Fixed effect (IV) odds ratio   
OR – IV (95% CI) 0.7677 (0.7196 to 0.8190) 0.7677 (0.7196 to 0.8190)
Z (P value) 8.0073 (< 0.0001) 8.01 (< 0.0001)
Q (P value) 39.48 (0.17) 39.48 (0.17)
I2 (95% CI) 0.1895 (0 to 0.4749) 0.1895
Fail-safe N (tolerance level) 270 (175) 270 *
Rank correlation tau ** (P value) 0.1799 (0.141) (0.141)
Egger's regression intercept (95% CI) -0.2955 (-0.7880 to 0.1970) -0.2955 (-0.7880 to 0.1970)
Macaskill's regression slope (P value) 0 (0.8396) 0 (0.840)
Trim-and-fill association measure (95% CI) 0.7744 (0.7260 to 0.8260) 0.774 (0.726 to 0.826)
Trim-and-fill imputed studies 6 6
Random effects (IV + t) odds ratio   
OR – IV + t (95% CI) 0.7619 (0.6825 to 0.8506) 0.7619 (0.6825 to 0.8506)
Z (P value) -4.84 (< 0.0001) -4.84 (< 0.0001)
t2 0.117 0.117
Trim-and-fill association measure (95% CI) 0.7828 (0.6907 to 0.8871) 0.783 (0.691 to 0.887)
Trim-and-fill imputed studies 6 6
  1. This table shows the odds ratio validation of the inverse variance fixed effect and random effects analyses with data set 1. Though not shown here, the results from Mantel-Haenszel and Peto weighting were evaluated similarly and so were the other association measures (risk difference and risk ratio). The process was repeated for each data set. (*): Results marked with '*' were produced by CMA. (**): The rank correlation tau is a continuity corrected tau-b. Abbreviations: "IV" = inverse variance weighting, "OR" = odds ratio, "CI" = confidence interval, "IV+t" = inverse variance plus tau, which refers to random effects weighting according to the DerSimonian-Laird method.